Sult2a8 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sult2a8provided by MGI
Official Full Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8provided by MGI
Primary source: MGI:MGI:1924221
See related: Ensembl:ENSMUSG00000030378 AllianceGenome:MGI:1924221
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: L-STL; mL-STL; 2810007J24Rik
Summary: Enables 3'-phosphoadenosine 5'-phosphosulfate binding activity and sulfotransferase activity. Involved in bile acid catabolic process. Located in cytosol. Is expressed in liver and olfactory epithelium. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human SULT2A1 (sulfotransferase family 2A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward liver adult (RPKM 19.7) See more
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Genomic context

Location:: 7 A1; 7 8.2 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (14144611..14180705, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (14410686..14446780, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of mouse cytosolic sulfotransferase SULT2A8 provides insight into sulfonation of 7alpha-hydroxyl bile acids.
Title: Structure of mouse cytosolic sulfotransferase SULT2A8 provides insight into sulfonation of 7α-hydroxyl bile acids.
Male-biased fasting-induced changes in hepatic tauro-cholic acid and plasma cholesterol in Sult2a8-haplodeficient mice.
Title: Male-biased fasting-induced changes in hepatic tauro-cholic acid and plasma cholesterol in Sult2a8-haplodeficient mice.
The crystal structure of mouse SULT2A8 reveals the mechanism of 7alpha-hydroxyl, bile acid sulfation.
Title: The crystal structure of mouse SULT2A8 reveals the mechanism of 7α-hydroxyl, bile acid sulfation.
findings suggested that substitutions of two amino acids, which might have occurred during the evolution of the mouse SULT2A8 gene, endowed mouse SULT2A8 the capacity to catalyze the 7-O-sulfation of bile acids
Title: The critical role of His48 in mouse cytosolic sulfotransferase SULT2A8 for the 7α-hydroxyl sulfation of bile acids.
a novel PPARalpha-dependent gene
Title: Identification and characterization of a novel PPARα-regulated and 7α-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding	IDA Inferred from Direct Assay more info	PubMed
enables 3'-phosphoadenosine 5'-phosphosulfate binding	ISO Inferred from Sequence Orthology more info
enables alcohol sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables bile-salt sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables steroid sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfotransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in bile acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ethanol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfation	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sulfotransferase 2A8

Names: glycochenodeoxycholate sulfotransferase 2A8; liver sulfotransferase-like protein; sulfotransferase-like protein 1

NP_001186235.1

EC 2.8.2.34

NP_780459.1

EC 2.8.2.34

XP_006540489.1

EC 2.8.2.34

XP_006540490.1

EC 2.8.2.34

XP_006540491.1

EC 2.8.2.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199306.1 → NP_001186235.1 sulfotransferase 2A8

See identical proteins and their annotated locations for NP_001186235.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC110880, AK050422

Consensus CDS

CCDS20833.1

UniProtKB/Swiss-Prot

B1PQU4, Q8BGL3

UniProtKB/TrEMBL

Q8K0B9

Related

ENSMUSP00000128428.3, ENSMUST00000168252.9

Conserved Domains (1) summary

pfam00685
Location:34 → 275

Sulfotransfer_1; Sulfotransferase domain
NM_175250.5 → NP_780459.1 sulfotransferase 2A8

See identical proteins and their annotated locations for NP_780459.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC110880, AK041070

Consensus CDS

CCDS20833.1

UniProtKB/Swiss-Prot

B1PQU4, Q8BGL3

UniProtKB/TrEMBL

Q8K0B9

Related

ENSMUSP00000066897.5, ENSMUST00000063509.11

Conserved Domains (1) summary

pfam00685
Location:34 → 275

Sulfotransfer_1; Sulfotransferase domain