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cbx3a chromobox homolog 3a (HP1 gamma homolog, Drosophila) [ Danio rerio (zebrafish) ]

Gene ID: 751689, updated on 11-Apr-2024

Summary

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Official Symbol
cbx3aprovided by ZNC
Official Full Name
chromobox homolog 3a (HP1 gamma homolog, Drosophila)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1158
See related
Ensembl:ENSDARG00000003860 AllianceGenome:ZFIN:ZDB-GENE-030131-1158
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cbx3; wu:fb61b02; zgc:153397
Summary
Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in chromatin organization and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in pericentric heterochromatin. Is expressed in ovary and testis. Orthologous to human CBX3 (chromobox 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See cbx3a in Genome Data Viewer
Location:
chromosome: 19
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (18132409..18135781, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (18669556..18672928, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108180149 Neighboring gene integrator complex subunit 8 Neighboring gene uncharacterized LOC103911055 Neighboring gene sorting nexin 10a Neighboring gene nfe2 like bZIP transcription factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of gonadotropin-inhibitory hormone receptor and its ligand. Ubuka T, et al. Gen Comp Endocrinol, 2014 Dec 1. PMID 25220854
  2. The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis. Li JY, et al. J Biol Chem, 2020 Jan 24. PMID 31852739, Free PMC Article
  3. Proteomic analysis of three gonad types of swamp eel reveals genes differentially expressed during sex reversal. Sheng Y, et al. Sci Rep, 2015 May 18. PMID 25985063, Free PMC Article
  4. Transcriptomic profile of early zebrafish PGCs by single cell sequencing. Zhang X, et al. PLoS One, 2019. PMID 31412047, Free PMC Article
  5. Repertoire of protein kinases encoded in the genome of zebrafish shows remarkably large population of PIM kinases. Rakshambikai R, et al. J Bioinform Comput Biol, 2014 Feb. PMID 24467753

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC153397

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of pericentric heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
chromobox protein homolog 3; chromobox protein homolog 3a
Names
chromobox homolog 3 (HP1 gamma homolog, Drosophila)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045402.1 → NP_001038867.1  chromobox protein homolog 3a

    See identical proteins and their annotated locations for NP_001038867.1

    Status: PROVISIONAL

    Source sequence(s)
    BC122267
    UniProtKB/TrEMBL
    Q0P455
    Related
    ENSDARP00000145648.1, ENSDART00000186609.1
    Conserved Domains (2) summary
    pfam00385
    Location:20 → 68
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
    pfam01393
    Location:113 → 164
    Chromo_shadow; Chromo shadow domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    18132409..18135781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173769.3 → XP_005173826.1  chromobox protein homolog 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BL16, F1QNF2
    Related
    ENSDARP00000009789.8, ENSDART00000012352.10
    Conserved Domains (2) summary
    pfam00385
    Location:23 → 71
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
    pfam01393
    Location:116 → 167
    Chromo_shadow; Chromo shadow domain
Nucleotide Protein Strain
Heading Accession and Version

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