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shank2.L SH3 and multiple ankyrin repeat domains 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 734458, updated on 11-Apr-2024

Summary

Official Symbol
shank2.L
Official Full Name
SH3 and multiple ankyrin repeat domains 2 L homeolog
Primary source
Xenbase:XB-GENE-984539
Locus tag
XELAEV_18021904mg
See related
EnsemblRapid:ENSXLAG00005023441
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
auts17; shank2; cortbp1; cttnbp1; prosap1; spank-3
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Genomic context

See shank2.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
28
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (10760654..11038765, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (10225565..10332988, complement)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 L homeolog Neighboring gene cortactin L homeolog Neighboring gene provisional ortholog of golgin B1 L homeolog Neighboring gene CD59 glycoprotein

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC115330

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables synaptic receptor adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SH3 and multiple ankyrin repeat domains protein 2
Names
SH3/ankyrin domain gene 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095939.1NP_001089408.1  SH3 and multiple ankyrin repeat domains protein 2

    See identical proteins and their annotated locations for NP_001089408.1

    Status: PROVISIONAL

    Source sequence(s)
    BC094169
    UniProtKB/Swiss-Prot
    Q52KW0
    Related
    ENSXLAP00005069349.1, ENSXLAT00005070883.1
    Conserved Domains (3) summary
    cd09506
    Location:12251290
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    smart00454
    Location:12271292
    SAM; Sterile alpha motif
    cd00992
    Location:54147
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    10760654..11038765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041589410.1XP_041445344.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8J1MU33, A0A974HMX6
    Conserved Domains (7) summary
    TIGR00570
    Location:12621389
    cdk7; CDK-activating kinase assembly factor MAT1
    PHA02875
    Location:167358
    PHA02875; ankyrin repeat protein; Provisional
    cd09506
    Location:17911856
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:520571
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:615708
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:229260
    ANK; ANK repeat [structural motif]
    cd17176
    Location:54141
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
  2. XM_041589409.1XP_041445343.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8J1MVJ5, A0A974HMX6
    Conserved Domains (7) summary
    TIGR00570
    Location:12631390
    cdk7; CDK-activating kinase assembly factor MAT1
    PHA02875
    Location:167358
    PHA02875; ankyrin repeat protein; Provisional
    cd09506
    Location:17921857
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:520571
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:615708
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:229260
    ANK; ANK repeat [structural motif]
    cd17176
    Location:54141
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
  3. XM_041589416.1XP_041445350.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A8J1MWH7, A0A974HMX6
    Conserved Domains (7) summary
    TIGR00570
    Location:12321359
    cdk7; CDK-activating kinase assembly factor MAT1
    PHA02875
    Location:167358
    PHA02875; ankyrin repeat protein; Provisional
    cd09506
    Location:17611826
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:520571
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:615708
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:229260
    ANK; ANK repeat [structural motif]
    cd17176
    Location:54141
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
  4. XM_041589414.1XP_041445348.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A8J1MVK1, A0A974HMX6
    Conserved Domains (7) summary
    TIGR00570
    Location:12421369
    cdk7; CDK-activating kinase assembly factor MAT1
    PHA02875
    Location:167358
    PHA02875; ankyrin repeat protein; Provisional
    cd09506
    Location:17711836
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:520571
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:615708
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:229260
    ANK; ANK repeat [structural motif]
    cd17176
    Location:54141
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
  5. XM_041589413.1XP_041445347.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A8J1MUB9, A0A974HMX6
    Related
    ENSXLAP00005069530.1, ENSXLAT00005071065.1
    Conserved Domains (7) summary
    TIGR00570
    Location:12431370
    cdk7; CDK-activating kinase assembly factor MAT1
    PHA02875
    Location:167358
    PHA02875; ankyrin repeat protein; Provisional
    cd09506
    Location:17721837
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:520571
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:615708
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:229260
    ANK; ANK repeat [structural motif]
    cd17176
    Location:54141
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
  6. XM_041589412.1XP_041445346.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8J1MV76, A0A974HMX6
    Conserved Domains (7) summary
    TIGR00570
    Location:12501377
    cdk7; CDK-activating kinase assembly factor MAT1
    PHA02875
    Location:167358
    PHA02875; ankyrin repeat protein; Provisional
    cd09506
    Location:17791844
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:520571
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:615708
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:229260
    ANK; ANK repeat [structural motif]
    cd17176
    Location:54141
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
  7. XM_041589411.1XP_041445345.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8J1MWH1, A0A974HMX6
    Conserved Domains (7) summary
    TIGR00570
    Location:12571384
    cdk7; CDK-activating kinase assembly factor MAT1
    PHA02875
    Location:167358
    PHA02875; ankyrin repeat protein; Provisional
    cd09506
    Location:17861851
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:520571
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:615708
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:229260
    ANK; ANK repeat [structural motif]
    cd17176
    Location:54141
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
  8. XM_041589420.1XP_041445354.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X11

    UniProtKB/TrEMBL
    A0A8J1MU47, A0A974HMX6
    Related
    ENSXLAP00005069630.1, ENSXLAT00005071165.1
    Conserved Domains (7) summary
    TIGR00570
    Location:12051332
    cdk7; CDK-activating kinase assembly factor MAT1
    PHA02875
    Location:167358
    PHA02875; ankyrin repeat protein; Provisional
    cd09506
    Location:17341799
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:520571
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:615708
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:229260
    ANK; ANK repeat [structural motif]
    cd17176
    Location:54141
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
  9. XM_041589419.1XP_041445353.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X10

    UniProtKB/TrEMBL
    A0A8J1MVK8, A0A974HMX6
    Related
    ENSXLAP00005069689.1, ENSXLAT00005071224.1
    Conserved Domains (7) summary
    TIGR00570
    Location:12191346
    cdk7; CDK-activating kinase assembly factor MAT1
    PHA02875
    Location:167358
    PHA02875; ankyrin repeat protein; Provisional
    cd09506
    Location:17481813
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:520571
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:615708
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:229260
    ANK; ANK repeat [structural motif]
    cd17176
    Location:54141
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
  10. XM_041589417.1XP_041445351.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X9

    UniProtKB/TrEMBL
    A0A8J1MV81, A0A974HMX6
    Conserved Domains (7) summary
    TIGR00570
    Location:12261353
    cdk7; CDK-activating kinase assembly factor MAT1
    PHA02875
    Location:167358
    PHA02875; ankyrin repeat protein; Provisional
    cd09506
    Location:17551820
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:520571
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:615708
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:229260
    ANK; ANK repeat [structural motif]
    cd17176
    Location:54141
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
  11. XM_041589415.1XP_041445349.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A8J1MU42, A0A974HMX6
    Related
    ENSXLAP00005069580.1, ENSXLAT00005071115.1
    Conserved Domains (7) summary
    TIGR00570
    Location:12361363
    cdk7; CDK-activating kinase assembly factor MAT1
    PHA02875
    Location:167358
    PHA02875; ankyrin repeat protein; Provisional
    cd09506
    Location:17651830
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:520571
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:615708
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:229260
    ANK; ANK repeat [structural motif]
    cd17176
    Location:54141
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
  12. XM_041589421.1XP_041445355.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X12

    UniProtKB/TrEMBL
    A0A8J1MWI4, A0A974HMX6
    Related
    ENSXLAP00005069734.1, ENSXLAT00005071269.1
    Conserved Domains (7) summary
    TIGR00570
    Location:11111238
    cdk7; CDK-activating kinase assembly factor MAT1
    PHA02875
    Location:167358
    PHA02875; ankyrin repeat protein; Provisional
    cd09506
    Location:16401705
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:520571
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:615708
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:229260
    ANK; ANK repeat [structural motif]
    cd17176
    Location:54141
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
  13. XM_041589422.1XP_041445356.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X13

    UniProtKB/TrEMBL
    A0A8J1MV87, A0A974HMX6
    Conserved Domains (7) summary
    TIGR00570
    Location:12371364
    cdk7; CDK-activating kinase assembly factor MAT1
    PHA02875
    Location:167358
    PHA02875; ankyrin repeat protein; Provisional
    cd09506
    Location:17661831
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:520571
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:615708
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:229260
    ANK; ANK repeat [structural motif]
    cd17176
    Location:54141
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
  14. XM_041589423.1XP_041445357.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X14

    UniProtKB/TrEMBL
    A0A8J1MUD0
    Conserved Domains (4) summary
    TIGR00570
    Location:8851012
    cdk7; CDK-activating kinase assembly factor MAT1
    cd09506
    Location:14141479
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:142193
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:237330
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  15. XM_041589425.1XP_041445359.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X15

    UniProtKB/TrEMBL
    A0A8J1MU52
    Related
    ENSXLAP00005069416.1, ENSXLAT00005070950.1
    Conserved Domains (4) summary
    TIGR00570
    Location:858985
    cdk7; CDK-activating kinase assembly factor MAT1
    cd09506
    Location:13871452
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:142193
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:237330
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...