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MAMU-DPA major histocompatibility complex, class II, DP alpha [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 717992, updated on 5-Mar-2024

Summary

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Gene symbol
MAMU-DPA
Gene description
major histocompatibility complex, class II, DP alpha
See related
Ensembl:ENSMMUG00000019371
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
Mamu-DPA1
Orthologs
human all
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Genomic context

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See MAMU-DPA in Genome Data Viewer
Location:
chromosome: 4
Exon count:
5
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (136430783..136440626)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (33909333..33919265, complement)

Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114677627 Neighboring gene uncharacterized LOC106997908 Neighboring gene major histocompatibility complex, class II, DP beta Neighboring gene elongation factor 1-alpha 1 pseudogene Neighboring gene major histocompatibility complex, class II, DO alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of Mamu-DPA1, Mamu-DQA1, and Mamu-DRA alleles in a cohort of Chinese rhesus macaques. Deng Q, et al. Immunogenetics, 2013 Dec. PMID 24042461
  2. The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers. Giraldo-Vela JP, et al. J Virol, 2008 Jan. PMID 17989178, Free PMC Article
  3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MHC class II protein complex binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptide antigen assembly with MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
major histocompatibility complex, class II, DP alpha
Names
MHC class II DPA
MHC class II antigen
Mhc DP-alpha
major histocompatibility complex class II
mamu-0008DPA01
mamu-89002DPA01

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048247.1 → NP_001041712.1  major histocompatibility complex, class II, DP alpha precursor

    See identical proteins and their annotated locations for NP_001041712.1

    Status: PROVISIONAL

    Source sequence(s)
    AB219099
    UniProtKB/TrEMBL
    A2TJ58, Q18PF3
    Conserved Domains (3) summary
    cd05767
    Location:117 → 210
    IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00993
    Location:36 → 113
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    pfam16196
    Location:208 → 259
    C1-set_C; C1-set C-terminal domain

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041757.1 Reference Mmul_10 Primary Assembly

    Range
    136430783..136440626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015136066.2 → XP_014991552.2  major histocompatibility complex, class II, DP alpha

    UniProtKB/TrEMBL
    A3F8Y2, B5M480, S6DFB2
    Related
    ENSMMUP00000025452.3, ENSMMUT00000027208.4
    Conserved Domains (2) summary
    cd05767
    Location:117 → 210
    IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00993
    Location:35 → 112
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
Nucleotide Protein
Heading Accession and Version

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