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HPN hepsin [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 707242, updated on 17-Aug-2024

Summary

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Official Symbol
HPNprovided by VGNC
Official Full Name
hepsinprovided by VGNC
Primary source
VGNC:VGNC:73513
Locus tag
EGK_10459
See related
Ensembl:ENSMMUG00000004844
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
13
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (34461934..34487399)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (30953120..30978972)

Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106994725 Neighboring gene uncharacterized LOC114674222 Neighboring gene sodium voltage-gated channel beta subunit 1 Neighboring gene uncharacterized LOC106994727 Neighboring gene FXYD domain containing ion transport regulator 3 Neighboring gene leucine rich repeat LGI family member 4 Neighboring gene FXYD domain containing ion transport regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type exopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine protease hepsin
Names
Serine protease hepsin
hepsin (transmembrane protease, serine 1)
XP_014979029.1
XP_014979030.1
XP_014979031.1
XP_014979032.1
XP_014979033.1
XP_014979034.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041772.1 Reference Mmul_10 Primary Assembly

    Range
    34461934..34487399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015123547.1 → XP_014979033.1  serine protease hepsin isoform X4

    UniProtKB/TrEMBL
    A0A8J8XTY4, F6QHU6, F6XEI3, G7NM37, H9F7G7
    Related
    ENSMMUP00000031673.2, ENSMMUT00000038576.3
    Conserved Domains (3) summary
    smart00020
    Location:162 → 400
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:163 → 400
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:50 → 159
    Hepsin-SRCR; Hepsin, SRCR

  2. XM_015123545.2 → XP_014979031.1  serine protease hepsin isoform X3

    UniProtKB/TrEMBL
    H9F7G7
    Conserved Domains (3) summary
    smart00020
    Location:162 → 400
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:163 → 400
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:50 → 159
    Hepsin-SRCR; Hepsin, SRCR

  3. XM_015123543.2 → XP_014979029.1  serine protease hepsin isoform X1

    UniProtKB/TrEMBL
    H9F7G7
    Conserved Domains (3) summary
    smart00020
    Location:216 → 454
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:217 → 454
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:104 → 213
    Hepsin-SRCR; Hepsin, SRCR

  4. XM_015123546.2 → XP_014979032.1  serine protease hepsin isoform X3

    UniProtKB/TrEMBL
    H9F7G7
    Conserved Domains (3) summary
    smart00020
    Location:162 → 400
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:163 → 400
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:50 → 159
    Hepsin-SRCR; Hepsin, SRCR

  5. XM_015123548.2 → XP_014979034.1  serine protease hepsin isoform X2

    UniProtKB/TrEMBL
    F6XEJ3, H9F7G7
    Related
    ENSMMUP00000031672.3, ENSMMUT00000038575.3
    Conserved Domains (3) summary
    smart00020
    Location:216 → 454
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:217 → 454
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:104 → 213
    Hepsin-SRCR; Hepsin, SRCR

  6. XM_015123544.2 → XP_014979030.1  serine protease hepsin isoform X2

    UniProtKB/TrEMBL
    F6XEJ3, H9F7G7
    Conserved Domains (3) summary
    smart00020
    Location:216 → 454
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:217 → 454
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:104 → 213
    Hepsin-SRCR; Hepsin, SRCR
Nucleotide Protein
Heading Accession and Version

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