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CHN1 chimerin 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 698697, updated on 17-Aug-2024

Summary

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Official Symbol
CHN1provided by VGNC
Official Full Name
chimerin 1provided by VGNC
Primary source
VGNC:VGNC:71041
See related
Ensembl:ENSMMUG00000021797
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See CHN1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
20
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (61896937..62096240, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (61807007..62006967, complement)

Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene WAS/WASL interacting protein family member 1 Neighboring gene uncharacterized LOC106992618 Neighboring gene cholinergic receptor nicotinic alpha 1 subunit Neighboring gene deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in ephrin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
N-chimaerin
Names
chimerin (chimaerin) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041765.1 Reference Mmul_10 Primary Assembly

    Range
    61896937..62096240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028830854.1 → XP_028686687.1  N-chimaerin isoform X6

    UniProtKB/TrEMBL
    G7N8C7
    Conserved Domains (3) summary
    cd10352
    Location:16 → 102
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:240 → 433
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cd20856
    Location:175 → 231
    C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins

  2. XM_028830851.1 → XP_028686684.1  N-chimaerin isoform X3

    UniProtKB/TrEMBL
    G7N8C7
    Conserved Domains (3) summary
    cd10352
    Location:29 → 115
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:253 → 446
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cd20856
    Location:188 → 244
    C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins

  3. XM_028830852.1 → XP_028686685.1  N-chimaerin isoform X4

    UniProtKB/TrEMBL
    G7N8C7
    Conserved Domains (3) summary
    cd10352
    Location:52 → 138
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:250 → 443
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    pfam00130
    Location:193 → 239
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  4. XM_028830853.1 → XP_028686686.1  N-chimaerin isoform X5

    UniProtKB/TrEMBL
    G7N8C7
    Conserved Domains (3) summary
    cd10352
    Location:52 → 138
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    pfam00130
    Location:216 → 265
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02570
    Location:276 → 423
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  5. XM_028830850.1 → XP_028686683.1  N-chimaerin isoform X1

    UniProtKB/TrEMBL
    G7N8C7
    Conserved Domains (3) summary
    cd10352
    Location:52 → 138
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:276 → 469
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    pfam00130
    Location:216 → 265
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  6. XM_028830856.1 → XP_028686689.1  N-chimaerin isoform X8

    UniProtKB/TrEMBL
    A0A1D5QQJ3
    Related
    ENSMMUP00000050321.2, ENSMMUT00000065320.2
    Conserved Domains (3) summary
    cd04372
    Location:214 → 407
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    pfam00130
    Location:154 → 203
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl15255
    Location:1 → 76
    SH2; Src homology 2 (SH2) domain

  7. XM_028830857.1 → XP_028686690.1  N-chimaerin isoform X11

    Related
    ENSMMUP00000050528.2, ENSMMUT00000070634.2
    Conserved Domains (2) summary
    cd04372
    Location:41 → 234
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cl00040
    Location:1 → 32
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  8. XM_015110403.2 → XP_014965889.1  N-chimaerin isoform X10

    UniProtKB/TrEMBL
    F7GRZ6
    Related
    ENSMMUP00000061883.1, ENSMMUT00000100576.1
    Conserved Domains (2) summary
    cd04372
    Location:86 → 279
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cd20856
    Location:21 → 77
    C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins

  9. XM_015110402.2 → XP_014965888.1  N-chimaerin isoform X9

    Conserved Domains (2) summary
    cd04372
    Location:96 → 289
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:36 → 88
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  10. XM_015110400.2 → XP_014965886.1  N-chimaerin isoform X2

    UniProtKB/TrEMBL
    F7ET58, G7N8C7
    Related
    ENSMMUP00000028709.4, ENSMMUT00000030674.4
    Conserved Domains (3) summary
    cd10352
    Location:42 → 128
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:266 → 459
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cd20856
    Location:201 → 257
    C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins

  11. XM_028830855.1 → XP_028686688.1  N-chimaerin isoform X7

    UniProtKB/TrEMBL
    F7ESU8, G7N8C7
    Related
    ENSMMUP00000028710.4, ENSMMUT00000030675.4
    Conserved Domains (3) summary
    cd10352
    Location:42 → 128
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:240 → 433
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cd20806
    Location:183 → 231
    C1_CHN; protein kinase C conserved region 1 (C1 domain) found in the chimaerin family
Nucleotide Protein
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