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PDE8A phosphodiesterase 8A [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 694750, updated on 5-Mar-2024

Summary

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Official Symbol
PDE8Aprovided by VGNC
Official Full Name
phosphodiesterase 8Aprovided by VGNC
Primary source
VGNC:VGNC:75924
See related
Ensembl:ENSMMUG00000019838
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See PDE8A in Genome Data Viewer
Location:
chromosome: 7
Exon count:
22
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (63306860..63461590, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (63157084..63312082)

Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114679476 Neighboring gene MKI67 FHA domain-interacting nucleolar phosphoprotein pseudogene Neighboring gene uncharacterized LOC106999271 Neighboring gene uncharacterized LOC114679479 Neighboring gene nascent polypeptide-associated complex subunit alpha, muscle-specific form-like Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene solute carrier family 28 member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
NP_001253573.1
XP_014998391.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001266644.1 → NP_001253573.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

    See identical proteins and their annotated locations for NP_001253573.1

    Status: PROVISIONAL

    Source sequence(s)
    JU322338
    UniProtKB/TrEMBL
    F7FU15, F7FU86
    Related
    ENSMMUP00000026089.2, ENSMMUT00000027886.4
    Conserved Domains (4) summary
    pfam08629
    Location:1 → 34
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:555 → 806
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:226 → 324
    PAS_9; PAS domain
    cl28069
    Location:121 → 346
    RocR; Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041760.1 Reference Mmul_10 Primary Assembly

    Range
    63306860..63461590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015142905.2 → XP_014998391.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

    UniProtKB/TrEMBL
    F7FU15
    Related
    ENSMMUP00000026090.3, ENSMMUT00000027887.4
    Conserved Domains (4) summary
    cd00130
    Location:236 → 330
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:561 → 813
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 34
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:232 → 330
    PAS_9; PAS domain
Nucleotide Protein
Heading Accession and Version

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