Clec4g C-type lectin domain family 4, member G [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clec4gprovided by RGD
Official Full Name: C-type lectin domain family 4, member Gprovided by RGD
Primary source: RGD:1597482
See related: Ensembl:ENSRNOG00000054013 AllianceGenome:RGD:1597482
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562320
Summary: Predicted to enable several functions, including monosaccharide binding activity; virus coreceptor activity; and virus receptor activity. Predicted to be involved in positive regulation of viral life cycle and viral entry into host cell. Predicted to act upstream of or within negative regulation of T cell mediated immunity and negative regulation of T cell proliferation. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human CLEC4G (C-type lectin domain family 4 member G). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 42.9), Spleen (RPKM 26.2) and 1 other tissue See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (6578266..6582913, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (1780370..1785027, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (2273649..2278594, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables carbohydrate derivative binding	ISO Inferred from Sequence Orthology more info
enables fructose binding	ISO Inferred from Sequence Orthology more info
enables mannose binding	ISO Inferred from Sequence Orthology more info
enables polysaccharide binding	ISO Inferred from Sequence Orthology more info
enables virus coreceptor activity	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of T cell mediated immunity	ISO Inferred from Sequence Orthology more info
acts_upstream_of alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of immature T cell proliferation in thymus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell mediated immunity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of immature T cell proliferation in thymus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral life cycle	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

Preferred Names: C-type lectin domain family 4 member G; C-type lectin domain family 4, member G

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_039089899.2 → XP_038945827.1 C-type lectin domain family 4 member G isoform X2

Conserved Domains (2) summary

smart00034
Location:165 → 197

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

COG3883
Location:43 → 154

CwlO1; Uncharacterized N-terminal domain of peptidoglycan hydrolase CwlO [Function unknown]
XM_039089898.2 → XP_038945826.1 C-type lectin domain family 4 member G isoform X1

UniProtKB/TrEMBL

A0A0G2JU13

Related

ENSRNOP00000068921.2

Conserved Domains (2) summary

cd03590
Location:165 → 289

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

COG3883
Location:43 → 154

CwlO1; Uncharacterized N-terminal domain of peptidoglycan hydrolase CwlO [Function unknown]
XM_063271727.1 → XP_063127797.1 C-type lectin domain family 4 member G isoform X3