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Tubg2 tubulin, gamma 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680991, updated on 17-Aug-2024

Summary

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Official Symbol
Tubg2provided by RGD
Official Full Name
tubulin, gamma 2provided by RGD
Primary source
RGD:1585798
See related
EnsemblRapid:ENSRNOG00000006494 AllianceGenome:RGD:1585798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic sister chromatid segregation. Predicted to be located in cytoplasmic microtubule; pericentriolar material; and spindle microtubule. Predicted to be part of gamma-tubulin complex. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Orthologous to human TUBG2 (tubulin gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 57.0), Testes (RPKM 50.5) and 9 other tissues See more
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Genomic context

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Location:
10q31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86591610..86597865)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86091205..86108053)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89069223..89075589)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480875 Neighboring gene reticulophagy regulator family member 3 Neighboring gene tubulin, gamma 1 Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H3 Neighboring gene contactin associated protein 1 Neighboring gene C-C motif chemokine receptor 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional analysis of bacterial artificial chromosomes in mammalian cells: mouse Cdc6 is associated with the mitotic spindle apparatus. Illenye S, et al. Genomics, 2004 Jan. PMID 14667810
  2. Mammalian RanBP1 regulates centrosome cohesion during mitosis. Di Fiore B, et al. J Cell Sci, 2003 Aug 15. PMID 12840069
  3. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Cheng A, et al. Genes Dev, 2007 Oct 1. PMID 17908927, Free PMC Article
  4. PEX14 is required for microtubule-based peroxisome motility in human cells. Bharti P, et al. J Cell Sci, 2011 May 15. PMID 21525035
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tubulin gamma-2 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399488.1 → NP_001386417.1  tubulin gamma-2 chain

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6A5N2, F1LUW9
    Related
    ENSRNOP00000088169.1, ENSRNOT00000098365.2
    Conserved Domains (1) summary
    cd02188
    Location:3 → 435
    gamma_tubulin; The gamma-tubulin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86591610..86597865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086820.2 → XP_038942748.1  tubulin gamma-2 chain isoform X1

    Conserved Domains (1) summary
    cd02188
    Location:37 → 361
    gamma_tubulin; The gamma-tubulin family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001191075.2: Suppressed sequence

    Description
    NM_001191075.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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