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Slc35a4 solute carrier family 35, member A4 [ Mus musculus (house mouse) ]

Gene ID: 67843, updated on 18-Sep-2024

Summary

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Official Symbol
Slc35a4provided by MGI
Official Full Name
solute carrier family 35, member A4provided by MGI
Primary source
MGI:MGI:1915093
See related
Ensembl:ENSMUSG00000033272 AllianceGenome:MGI:1915093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610030J16Rik
Summary
Predicted to enable pyrimidine nucleotide-sugar transmembrane transporter activity. Predicted to be involved in positive regulation of translation in response to stress. Predicted to act upstream of or within carbohydrate transport. Predicted to be located in Golgi apparatus. Predicted to be integral component of Golgi membrane. Is expressed in axial musculature; cranium; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human SLC35A4 (solute carrier family 35 member A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 89.9), adrenal adult (RPKM 87.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B2; 18 19.46 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36812268..36816915)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36679215..36683862)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E5653 Neighboring gene steroid receptor RNA activator 1 Neighboring gene amyloid beta precursor protein binding family B member 3 Neighboring gene STARR-positive B cell enhancer ABC_E8708 Neighboring gene Riken cDNA E230025N22 gene Neighboring gene STARR-seq mESC enhancer starr_44297 Neighboring gene predicted gene, 41699

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC143687, MGC143688

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of translation in response to stress ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable UDP-sugar transporter protein SLC35A4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083317.2 → NP_001076786.1  probable UDP-sugar transporter protein SLC35A4

    See identical proteins and their annotated locations for NP_001076786.1

    Status: VALIDATED

    Source sequence(s)
    AC115631
    Consensus CDS
    CCDS29158.1
    UniProtKB/Swiss-Prot
    Q8BMH3, Q99JK8, Q9D0A7, Q9D321
    Related
    ENSMUSP00000129718.2, ENSMUST00000050476.11
    Conserved Domains (1) summary
    pfam04142
    Location:83 → 320
    Nuc_sug_transp; Nucleotide-sugar transporter

  2. NM_001360989.2 → NP_001347918.1  probable UDP-sugar transporter protein SLC35A4

    Status: VALIDATED

    Source sequence(s)
    AC115631
    Consensus CDS
    CCDS29158.1
    UniProtKB/Swiss-Prot
    Q8BMH3, Q99JK8, Q9D0A7, Q9D321
    Conserved Domains (1) summary
    pfam04142
    Location:83 → 320
    Nuc_sug_transp; Nucleotide-sugar transporter

  3. NM_026404.3 → NP_080680.2  probable UDP-sugar transporter protein SLC35A4

    See identical proteins and their annotated locations for NP_080680.2

    Status: VALIDATED

    Source sequence(s)
    AC115631
    Consensus CDS
    CCDS29158.1
    UniProtKB/Swiss-Prot
    Q8BMH3, Q99JK8, Q9D0A7, Q9D321
    Related
    ENSMUSP00000036081.7, ENSMUST00000036158.7
    Conserved Domains (1) summary
    pfam04142
    Location:83 → 320
    Nuc_sug_transp; Nucleotide-sugar transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36812268..36816915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D321.1 GenPept UniProtKB/Swiss-Prot:Q9D321

Gene LinkOut

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