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LOC6726131 furin-like protease 2 [ Drosophila simulans ]

Gene ID: 6726131, updated on 15-Sep-2023

Summary

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Gene symbol
LOC6726131
Gene description
furin-like protease 2
Locus tag
Dsimw501_GD17282
See related
EnsemblRapid:LOC6726131
Gene type
protein coding
RefSeq status
MODEL
Organism
Drosophila simulans
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Fur2; Fur2-PB; Fur2-PC; Fur2-PD; Fur2-PE; Fur2-PF; Fur2-PG; Fur2-PH; Fur2-PI; Fur2-PJ; GD17282; Dsim\Fur2; GD17282-PB; GD17282-PC; GD17282-PD; GD17282-PE; GD17282-PF; GD17282-PG; GD17282-PH; GD17282-PI; GD17282-PJ
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Genomic context

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Location:
chromosome: X
Exon count:
16
Annotation release Status Assembly Chr Location
103 current Prin_Dsim_3.1 (GCF_016746395.2) X NC_052525.2 (15820959..15829757)
102 previous assembly Prin_Dsim_3.0 (GCF_016746395.1) X NC_052525.1 (15821010..15829711)

Chromosome X - NC_052525.2Genomic Context describing neighboring genes Neighboring gene splicing factor U2AF 50 kDa subunit Neighboring gene uncharacterized LOC6740161 Neighboring gene protein no-on-transient A Neighboring gene uncharacterized LOC6726132 Neighboring gene trimeric intracellular cation channel type 1B.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Strong regional heterogeneity in base composition evolution on the Drosophila X chromosome. Ko WY, et al. Genetics, 2006 Sep. PMID 16547109, Free PMC Article
  2. Molecular evolution in the Drosophila melanogaster species subgroup: frequent parameter fluctuations on the timescale of molecular divergence. Akashi H, et al. Genetics, 2006 Mar. PMID 16387879, Free PMC Article
  3. Evolution of genes and genomes on the Drosophila phylogeny. Drosophila 12 Genomes Consortium, et al. Nature, 2007 Nov 8. PMID 17994087

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
furin-like protease 2
Names
Dsim\Fur2-PB
Dsim\Fur2-PC
Dsim\Fur2-PD
Dsim\Fur2-PE
Dsim\Fur2-PF
Dsim\Fur2-PG
Dsim\Fur2-PH
Dsim\Fur2-PI
Dsim\Fur2-PJ
Dsim\GD17282
Dsim\GD17282-PB
Dsim\GD17282-PC
Dsim\GD17282-PD
Dsim\GD17282-PE
Dsim\GD17282-PF
Dsim\GD17282-PG
Dsim\GD17282-PH
Dsim\GD17282-PI
Dsim\GD17282-PJ
dsim_GLEANR_17422
furin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Drosophila simulans Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Prin_Dsim_3.1

Genomic

  1. NC_052525.2 Reference Prin_Dsim_3.1

    Range
    15820959..15829757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016174029.3 → XP_016039641.1  furin-like protease 2 isoform X2

    UniProtKB/TrEMBL
    B4R5T4
    Related
    XP_016039641.1, XM_016174029.3
    Conserved Domains (8) summary
    cd04059
    Location:373 → 669
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:1206 → 1250
    FU; Furin-like repeats
    cd00064
    Location:1111 → 1158
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00082
    Location:406 → 695
    Peptidase_S8; Subtilase family
    pfam00757
    Location:961 → 1121
    Furin-like; Furin-like cysteine rich region
    pfam01483
    Location:756 → 844
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:1063 → 1227
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:240 → 316
    S8_pro-domain; Peptidase S8 pro-domain

  2. XM_016174028.3 → XP_016039640.1  furin-like protease 2 isoform X4

    UniProtKB/TrEMBL
    B4R5T4
    Related
    XP_016039640.1, XM_016174028.3
    Conserved Domains (8) summary
    cd04059
    Location:349 → 645
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:1182 → 1226
    FU; Furin-like repeats
    cd00064
    Location:1087 → 1134
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00082
    Location:382 → 671
    Peptidase_S8; Subtilase family
    pfam00757
    Location:937 → 1097
    Furin-like; Furin-like cysteine rich region
    pfam01483
    Location:732 → 820
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:1039 → 1203
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:240 → 316
    S8_pro-domain; Peptidase S8 pro-domain

  3. XM_016174025.3 → XP_016039637.1  furin-like protease 2 isoform X1

    UniProtKB/TrEMBL
    B4R5T4
    Related
    XP_016039637.1, XM_016174025.3
    Conserved Domains (8) summary
    cd04059
    Location:373 → 672
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:1209 → 1253
    FU; Furin-like repeats
    cd00064
    Location:1114 → 1161
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00082
    Location:409 → 698
    Peptidase_S8; Subtilase family
    pfam00757
    Location:964 → 1124
    Furin-like; Furin-like cysteine rich region
    pfam01483
    Location:759 → 847
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:1066 → 1230
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:240 → 316
    S8_pro-domain; Peptidase S8 pro-domain

  4. XM_016174031.3 → XP_016039643.1  furin-like protease 2 isoform X3

    UniProtKB/TrEMBL
    B4R5T4
    Related
    XP_016039643.1, XM_016174031.3
    Conserved Domains (8) summary
    cd04059
    Location:349 → 648
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:1185 → 1229
    FU; Furin-like repeats
    cd00064
    Location:1090 → 1137
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00082
    Location:385 → 674
    Peptidase_S8; Subtilase family
    pfam00757
    Location:940 → 1100
    Furin-like; Furin-like cysteine rich region
    pfam01483
    Location:735 → 823
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:1042 → 1206
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:240 → 316
    S8_pro-domain; Peptidase S8 pro-domain

  5. XM_016174030.3 → XP_016039642.1  furin-like protease 2 isoform X1

    UniProtKB/TrEMBL
    B4R5T4
    Related
    XP_016039642.1, XM_016174030.3
    Conserved Domains (8) summary
    cd04059
    Location:373 → 672
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:1209 → 1253
    FU; Furin-like repeats
    cd00064
    Location:1114 → 1161
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00082
    Location:409 → 698
    Peptidase_S8; Subtilase family
    pfam00757
    Location:964 → 1124
    Furin-like; Furin-like cysteine rich region
    pfam01483
    Location:759 → 847
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:1066 → 1230
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:240 → 316
    S8_pro-domain; Peptidase S8 pro-domain
Nucleotide Protein Strain
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