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Nedd4 E3 ubiquitin-protein ligase Nedd4 [ Drosophila ananassae ]

Gene ID: 6493408, updated on 23-May-2024

Summary

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Gene symbol
Nedd4
Gene description
E3 ubiquitin-protein ligase Nedd4
Locus tag
Dana_GF10539
See related
EnsemblRapid:LOC6493408
Gene type
protein coding
RefSeq status
MODEL
Organism
Drosophila ananassae
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
GF10539; GF10539-PB; GF10539-PC; GF10539-PD; GF10539-PE; GF10539-PF; GF10539-PG; GF10539-PH; GF10539-PI
Orthologs
fruit fly all
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Genomic context

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See Nedd4 in Genome Data Viewer
Location:
chromosome: 2R
Exon count:
23
Annotation release Status Assembly Chr Location
102 current ASM1763931v2 (GCF_017639315.1) 2R NC_057928.1 (12741051..12755927, complement)
101 previous assembly DanaRS2.1 (GCF_003285975.2) Unplaced Scaffold NW_022473439.1 (14287350..14301678)

Chromosome 2R - NC_057928.1Genomic Context describing neighboring genes Neighboring gene brachyurin Neighboring gene serine protease 1 Neighboring gene enhancer of mRNA-decapping protein 3 Neighboring gene putative RNA-binding protein Luc7-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of genes and genomes on the Drosophila phylogeny. Drosophila 12 Genomes Consortium, et al. Nature, 2007 Nov 8. PMID 17994087

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sodium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of sodium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Nedd-4
Names
Dana\GF10539
Dana\GF10539-PB
Dana\GF10539-PC
Dana\GF10539-PD
Dana\GF10539-PE
Dana\GF10539-PF
Dana\GF10539-PG
Dana\GF10539-PH
Dana\GF10539-PI
dana_GLEANR_10493

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Drosophila ananassae Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1763931v2

Genomic

  1. NC_057928.1 Reference ASM1763931v2

    Range
    12741051..12755927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_032454415.2 → XP_032310306.1  E3 ubiquitin-protein ligase Nedd-4 isoform X2

    UniProtKB/TrEMBL
    A0A0P8YHZ9
    Related
    XP_032310306.1, XM_032454415.2
    Conserved Domains (3) summary
    cd04033
    Location:68 → 198
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    COG5021
    Location:543 → 1019
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:242 → 271
    WW; WW domain

  2. XM_014908880.3 → XP_014764366.1  E3 ubiquitin-protein ligase Nedd-4 isoform X7

    UniProtKB/TrEMBL
    A0A0P8YHZ9, A0A0P9C4D4
    Related
    XP_014764366.1, XM_014908880.3
    Conserved Domains (5) summary
    cd04033
    Location:68 → 201
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:405 → 437
    WW; Domain with 2 conserved Trp (W) residues
    COG5021
    Location:78 → 827
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00078
    Location:474 → 827
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:245 → 274
    WW; WW domain

  3. XM_032454416.2 → XP_032310307.1  E3 ubiquitin-protein ligase Nedd-4 isoform X3

    UniProtKB/TrEMBL
    A0A0P8YHZ9
    Related
    XP_032310307.1, XM_032454416.2
    Conserved Domains (3) summary
    cd04033
    Location:68 → 201
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    COG5021
    Location:533 → 1009
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:245 → 274
    WW; WW domain

  4. XM_001957650.4 → XP_001957686.2  E3 ubiquitin-protein ligase Nedd-4 isoform X5

    UniProtKB/TrEMBL
    A0A0P8YHZ9, B3M4J8
    Related
    XP_001957686.2, XM_001957650.4
    Conserved Domains (5) summary
    cd04033
    Location:68 → 201
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:564 → 596
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:657 → 986
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:633 → 986
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:245 → 274
    WW; WW domain

  5. XM_032454414.2 → XP_032310305.1  E3 ubiquitin-protein ligase Nedd-4 isoform X1

    UniProtKB/TrEMBL
    A0A0P8YHZ9
    Related
    XP_032310305.1, XM_032454414.2
    Conserved Domains (3) summary
    cd04033
    Location:68 → 201
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    COG5021
    Location:546 → 1022
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:245 → 274
    WW; WW domain

  6. XM_014908881.3 → XP_014764367.1  E3 ubiquitin-protein ligase Nedd-4 isoform X6

    UniProtKB/TrEMBL
    A0A0P8YHZ9, A0A0P8ZVI2
    Related
    XP_014764367.1, XM_014908881.3
    Conserved Domains (5) summary
    cd04033
    Location:68 → 201
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:499 → 531
    WW; Domain with 2 conserved Trp (W) residues
    COG5021
    Location:78 → 921
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00078
    Location:568 → 921
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:245 → 274
    WW; WW domain

  7. XM_032454417.2 → XP_032310308.1  E3 ubiquitin-protein ligase Nedd-4 isoform X4

    UniProtKB/TrEMBL
    A0A0P9AL80
    Related
    XP_032310308.1, XM_032454417.2
    Conserved Domains (3) summary
    cd04033
    Location:33 → 166
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    COG5021
    Location:511 → 987
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:210 → 239
    WW; WW domain

  8. XM_032454419.2 → XP_032310310.1  E3 ubiquitin-protein ligase Nedd-4 isoform X4

    UniProtKB/TrEMBL
    A0A0P9AL80
    Related
    XP_032310310.1, XM_032454419.2
    Conserved Domains (3) summary
    cd04033
    Location:33 → 166
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    COG5021
    Location:511 → 987
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:210 → 239
    WW; WW domain

  9. XM_044714548.1 → XP_044570483.1  E3 ubiquitin-protein ligase Nedd-4 isoform X9

    UniProtKB/TrEMBL
    A0A0P9AL80
    Related
    XP_044570483.1, XM_044714548.1
    Conserved Domains (2) summary
    cd04033
    Location:33 → 163
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    COG5021
    Location:207 → 789
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

  10. XM_044714547.1 → XP_044570482.1  E3 ubiquitin-protein ligase Nedd-4 isoform X8

    UniProtKB/TrEMBL
    A0A0P8XV29, A0A0P9AL80
    Related
    XP_044570482.1, XM_044714547.1
    Conserved Domains (1) summary
    COG5021
    Location:21 → 792
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

  11. XM_014908879.3 → XP_014764365.1  E3 ubiquitin-protein ligase Nedd-4 isoform X10

    UniProtKB/TrEMBL
    A0A0N8P106
    Related
    XP_014764365.1, XM_014908879.3
    Conserved Domains (4) summary
    smart00456
    Location:107 → 139
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:200 → 529
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:176 → 529
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:57 → 86
    WW; WW domain
Nucleotide Protein Strain
Heading Accession and Version

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