CHFR checkpoint with forkhead and ring finger domains [Bos taurus (cattle)] - Gene

Summary

Official Symbol: CHFRprovided by VGNC
Official Full Name: checkpoint with forkhead and ring finger domainsprovided by VGNC
Primary source: VGNC:VGNC:27288
See related: Ensembl:ENSBTAG00000013951
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	17	NC_037344.1 (44386496..44411465)

Chromosome 17 - NC_037344.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in mitotic cell cycle checkpoint signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase CHFR

NP_001192403.2

EC 2.3.2.27

XP_005217736.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205474.3 → NP_001192403.2 E3 ubiquitin-protein ligase CHFR

Status: PROVISIONAL

Source sequence(s)

NKLS02000017

UniProtKB/TrEMBL

E1BBP0

Related

ENSBTAP00000018544.6, ENSBTAT00000018544.7

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

Range

44386496..44411465

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005217679.5 → XP_005217736.2 E3 ubiquitin-protein ligase CHFR isoform X1

UniProtKB/TrEMBL

E1BBP0

Related

ENSBTAP00000077304.1, ENSBTAT00000091157.1

Conserved Domains (3) summary

cd00060
Location:16 → 105

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd16503
Location:300 → 343

RING-HC_CHFR; RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)

cl28410
Location:298 → 419

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]