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SH2B1 SH2B adaptor protein 1 [ Canis lupus familiaris (dog) ]

Gene ID: 612792, updated on 17-Aug-2024

Summary

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Official Symbol
SH2B1provided by VGNC
Official Full Name
SH2B adaptor protein 1provided by VGNC
Primary source
VGNC:VGNC:46109
See related
Ensembl:ENSCAFG00845003120
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See SH2B1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (18507858..18516906)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (19950137..19959175)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (18538095..18547144)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (18307240..18316447)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (18222112..18231023)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111096259 Neighboring gene Tu translation elongation factor, mitochondrial Neighboring gene uncharacterized LOC106558930 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene CD19 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables transmembrane receptor protein tyrosine kinase adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
SH2B adapter protein 1; LOW QUALITY PROTEIN: SH2B adapter protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    18507858..18516906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038668754.1 → XP_038524682.1  SH2B adapter protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0LU70
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  2. XM_038668755.1 → XP_038524683.1  SH2B adapter protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0LU70
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  3. XM_038668757.1 → XP_038524685.1  SH2B adapter protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LU70
    Conserved Domains (3) summary
    cd10346
    Location:450 → 546
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  4. XM_038668756.1 → XP_038524684.1  SH2B adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R985, A0A8I3RR61, A0A8I3RR63, A0A8P0NIJ9, A0A8P0TBR9
    Related
    ENSCAFP00845004404.1, ENSCAFT00845005549.1
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  5. XM_038668758.1 → XP_038524686.1  SH2B adapter protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0R985, A0A8I3RR61
    Related
    ENSCAFP00845004392.1, ENSCAFT00845005535.1
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  6. XM_038668759.1 → XP_038524687.1  SH2B adapter protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KW38, A0A8C0PSB8
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    18307240..18316447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038478712.1 → XP_038334640.1  SH2B adapter protein 1 isoform X5

    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  2. XM_038478713.1 → XP_038334641.1  SH2B adapter protein 1 isoform X5

    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  3. XM_038478715.1 → XP_038334643.1  SH2B adapter protein 1 isoform X2

    Conserved Domains (3) summary
    cd10346
    Location:450 → 546
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  4. XM_038478714.1 → XP_038334642.1  SH2B adapter protein 1 isoform X1

    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  5. XM_038478716.1 → XP_038334644.1  SH2B adapter protein 1 isoform X3

  6. XM_038478717.1 → XP_038334645.1  SH2B adapter protein 1 isoform X4

    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    18222112..18231023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038604039.1 → XP_038459967.1  LOW QUALITY PROTEIN: SH2B adapter protein 1 isoform X5

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    18538095..18547144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038539957.1 → XP_038395885.1  SH2B adapter protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0LU70
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  2. XM_038539958.1 → XP_038395886.1  SH2B adapter protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0LU70
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  3. XM_038539960.1 → XP_038395888.1  SH2B adapter protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LU70
    Conserved Domains (3) summary
    cd10346
    Location:450 → 546
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  4. XM_038539959.1 → XP_038395887.1  SH2B adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R985, A0A8I3RR61, A0A8I3RR63, A0A8P0NIJ9, A0A8P0TBR9
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  5. XM_038539961.1 → XP_038395889.1  SH2B adapter protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0R985, A0A8I3RR61
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  6. XM_038539962.1 → XP_038395890.1  SH2B adapter protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KW38, A0A8C0PSB8
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    19950137..19959175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005621371.4 → XP_005621428.1  SH2B adapter protein 1 isoform X5

    See identical proteins and their annotated locations for XP_005621428.1

    UniProtKB/TrEMBL
    A0A8C0LU70
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  2. XM_005621373.4 → XP_005621430.1  SH2B adapter protein 1 isoform X5

    See identical proteins and their annotated locations for XP_005621430.1

    UniProtKB/TrEMBL
    A0A8C0LU70
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  3. XM_014114513.3 → XP_013969988.1  SH2B adapter protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LU70
    Conserved Domains (3) summary
    cd10346
    Location:450 → 546
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  4. XM_014114512.3 → XP_013969987.1  SH2B adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R985, A0A8I3RR61, A0A8I3RR63, A0A8P0NIJ9, A0A8P0TBR9
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  5. XM_014114514.3 → XP_013969989.1  SH2B adapter protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q010, A0A8P0NIJ9
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper

  6. XM_014114515.3 → XP_013969990.1  SH2B adapter protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KW38, A0A8C0PSB8
    Conserved Domains (3) summary
    cd10346
    Location:521 → 617
    SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
    cd01231
    Location:246 → 378
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:26 → 81
    Phe_ZIP; Phenylalanine zipper
Nucleotide Protein
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