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ERN1 endoplasmic reticulum to nucleus signaling 1 [ Canis lupus familiaris (dog) ]

Gene ID: 610766, updated on 5-Mar-2024

Summary

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Official Symbol
ERN1provided by VGNC
Official Full Name
endoplasmic reticulum to nucleus signaling 1provided by VGNC
Primary source
VGNC:VGNC:40464
See related
Ensembl:ENSCAFG00845022274
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See ERN1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
26
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (13591579..13669839, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (12825652..12903073, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (14918080..14996082)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (12538344..12616358, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (14915804..14993944)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene proline rich 29 Neighboring gene intercellular adhesion molecule 2 Neighboring gene uncharacterized LOC119873254 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORD104 Neighboring gene small nucleolar RNA SNORA76

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of IRE1-TRAF2-ASK1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase/endoribonuclease IRE1; LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1
Names
endoplasmic reticulum to nucleus signalling 1
XP_005624312.1
XP_022278543.1
XP_022278544.1
XP_022278545.1
XP_022278546.1
XP_022278547.1
XP_038341094.1
XP_038341095.1
XP_038341096.1
XP_038341097.1
XP_038341098.1
XP_038341099.1
XP_038341100.1
XP_038402792.1
XP_038402793.1
XP_038402795.1
XP_038402796.1
XP_038402797.1
XP_038402798.1
XP_038402799.1
XP_038466769.1
XP_038531941.1
XP_038531942.1
XP_038531943.1
XP_038531944.1
XP_038531945.1
XP_038531946.1
XP_038531947.1
XP_853409.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    13591579..13669839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038676013.1 → XP_038531941.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0NGF4, A0A8C0SZA9, A0A8I3PJV6
    Related
    ENSCAFP00845030974.1, ENSCAFT00845039523.1
    Conserved Domains (3) summary
    cd09769
    Location:30 → 298
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:834 → 959
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:566 → 831
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

  2. XM_038676019.1 → XP_038531947.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:670 → 795
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:402 → 667
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 134
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  3. XM_038676017.1 → XP_038531945.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:717 → 842
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:449 → 714
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 181
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  4. XM_038676018.1 → XP_038531946.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:670 → 795
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:402 → 667
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 134
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  5. XM_038676015.1 → XP_038531943.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:717 → 842
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:449 → 714
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 181
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  6. XM_038676016.1 → XP_038531944.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:717 → 842
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:449 → 714
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 181
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  7. XM_038676014.1 → XP_038531942.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NK15
    Conserved Domains (3) summary
    cd09769
    Location:16 → 284
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:820 → 945
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:552 → 817
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    12538344..12616358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038485166.1 → XP_038341094.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X4

    Conserved Domains (3) summary
    cd09769
    Location:30 → 298
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:834 → 959
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:566 → 831
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

  2. XM_038485172.1 → XP_038341100.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

    Conserved Domains (3) summary
    cd10422
    Location:670 → 795
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:402 → 667
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 134
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  3. XM_038485170.1 → XP_038341098.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

    Conserved Domains (3) summary
    cd10422
    Location:717 → 842
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:449 → 714
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 181
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  4. XM_038485171.1 → XP_038341099.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

    Conserved Domains (3) summary
    cd10422
    Location:670 → 795
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:402 → 667
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 134
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  5. XM_038485168.1 → XP_038341096.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

    Conserved Domains (3) summary
    cd10422
    Location:717 → 842
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:449 → 714
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 181
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  6. XM_038485169.1 → XP_038341097.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

    Conserved Domains (3) summary
    cd10422
    Location:717 → 842
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:449 → 714
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 181
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  7. XM_038485167.1 → XP_038341095.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1

    Conserved Domains (3) summary
    cd09769
    Location:16 → 284
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:820 → 945
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:552 → 817
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    14915804..14993944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038610841.1 → XP_038466769.1  LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1 isoform X4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    14918080..14996082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038546864.1 → XP_038402792.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0NGF4, A0A8P0NDV4

  2. XM_038546867.1 → XP_038402795.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:717 → 842
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:449 → 714
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 181
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  3. XM_038546870.1 → XP_038402798.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:670 → 795
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:402 → 667
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 134
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  4. XM_038546869.1 → XP_038402797.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:717 → 842
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:449 → 714
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 181
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  5. XM_038546871.1 → XP_038402799.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:670 → 795
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:402 → 667
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 134
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  6. XM_038546868.1 → XP_038402796.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:717 → 842
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:449 → 714
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 181
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  7. XM_038546865.1 → XP_038402793.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0NK15

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    12825652..12903073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_848316.5 → XP_853409.3  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0NGF4, A0A8P0NDV4
    Conserved Domains (4) summary
    cd09769
    Location:30 → 298
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:834 → 959
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    smart00220
    Location:569 → 830
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13982
    Location:566 → 831
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

  2. XM_022422839.2 → XP_022278547.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:670 → 795
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:402 → 667
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 134
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  3. XM_022422837.2 → XP_022278545.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:717 → 842
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:449 → 714
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 181
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  4. XM_022422838.2 → XP_022278546.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:670 → 795
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:402 → 667
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 134
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  5. XM_022422835.2 → XP_022278543.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:717 → 842
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:449 → 714
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 181
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  6. XM_022422836.2 → XP_022278544.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PJE1
    Conserved Domains (3) summary
    cd10422
    Location:717 → 842
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:449 → 714
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 181
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  7. XM_005624255.3 → XP_005624312.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X6

    See identical proteins and their annotated locations for XP_005624312.1

    UniProtKB/TrEMBL
    A0A8C0NK15
    Conserved Domains (4) summary
    cd09769
    Location:17 → 285
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:821 → 946
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    smart00220
    Location:556 → 817
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13982
    Location:553 → 818
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
Nucleotide Protein
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