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INSIG2 insulin induced gene 2 [ Canis lupus familiaris (dog) ]

Gene ID: 610496, updated on 17-Aug-2024

Summary

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Official Symbol
INSIG2provided by VGNC
Official Full Name
insulin induced gene 2provided by VGNC
Primary source
VGNC:VGNC:42040
See related
Ensembl:ENSCAFG00845005970
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 19 NC_051823.1 (33190437..33210363, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 19 NC_006601.4 (32063758..32083699, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 19 NC_049240.1 (33222123..33242041, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 19 NC_049279.1 (31864844..31884780, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 19 NC_049760.1 (32033058..32052956, complement)

Chromosome 19 - NC_051823.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102151514 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102151623 Neighboring gene U4 spliceosomal RNA Neighboring gene coiled-coil domain containing 93 Neighboring gene 5-hydroxytryptamine receptor 5B-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two candidate genes (FTO and INSIG2) for fat accumulation in four canids: chromosome mapping, gene polymorphisms and association studies of body and skin weight of red foxes. Grzes M, et al. Cytogenet Genome Res, 2011. PMID 21846970

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Strong association has been found between the presence of SNPs in the FTO and INSIG2 genes and adipose tissue accumulation in canids.
    Title: Two candidate genes (FTO and INSIG2) for fat accumulation in four canids: chromosome mapping, gene polymorphisms and association studies of body and skin weight of red foxes.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in SREBP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SREBP-SCAP complex retention in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of SREBP-SCAP-Insig complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin-induced gene 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051823.1 Reference ROS_Cfam_1.0

    Range
    33190437..33210363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038426081.1 → XP_038282009.1  insulin-induced gene 2 protein isoform X2

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 142
    INSIG; Insulin-induced protein (INSIG)

  2. XM_038426077.1 → XP_038282005.1  insulin-induced gene 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMJ2, A0A8C0NZL6, A0A8C0QLG9, A0A8I3MQT8, A0A8I3RUF9
    Related
    ENSCAFP00845008244.1, ENSCAFT00845010586.1
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  3. XM_038426082.1 → XP_038282010.1  insulin-induced gene 2 protein isoform X3

    Conserved Domains (1) summary
    pfam07281
    Location:1 → 103
    INSIG; Insulin-induced protein (INSIG)

  4. XM_038426078.1 → XP_038282006.1  insulin-induced gene 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMJ2, A0A8C0NZL6, A0A8C0QLG9, A0A8I3MQT8, A0A8I3RUF9
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  5. XM_038426079.1 → XP_038282007.1  insulin-induced gene 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMJ2, A0A8C0NZL6, A0A8C0QLG9, A0A8I3MQT8, A0A8I3RUF9
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  6. XM_038426083.1 → XP_038282011.1  insulin-induced gene 2 protein isoform X4

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 112
    INSIG; Insulin-induced protein (INSIG)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049279.1 Alternate UMICH_Zoey_3.1

    Range
    31864844..31884780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038502268.1 → XP_038358196.1  insulin-induced gene 2 protein isoform X2

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 142
    INSIG; Insulin-induced protein (INSIG)

  2. XM_038502265.1 → XP_038358193.1  insulin-induced gene 2 protein isoform X1

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  3. XM_038502269.1 → XP_038358197.1  insulin-induced gene 2 protein isoform X3

    Conserved Domains (1) summary
    pfam07281
    Location:1 → 103
    INSIG; Insulin-induced protein (INSIG)

  4. XM_038502266.1 → XP_038358194.1  insulin-induced gene 2 protein isoform X1

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  5. XM_038502267.1 → XP_038358195.1  insulin-induced gene 2 protein isoform X1

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  6. XM_038502270.1 → XP_038358198.1  insulin-induced gene 2 protein isoform X4

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 112
    INSIG; Insulin-induced protein (INSIG)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049760.1 Alternate UNSW_CanFamBas_1.0

    Range
    32033058..32052956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038629071.1 → XP_038484999.1  insulin-induced gene 2 protein isoform X2

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 142
    INSIG; Insulin-induced protein (INSIG)

  2. XM_038629068.1 → XP_038484996.1  insulin-induced gene 2 protein isoform X1

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  3. XM_038629072.1 → XP_038485000.1  insulin-induced gene 2 protein isoform X3

    Conserved Domains (1) summary
    pfam07281
    Location:1 → 103
    INSIG; Insulin-induced protein (INSIG)

  4. XM_038629069.1 → XP_038484997.1  insulin-induced gene 2 protein isoform X1

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  5. XM_038629070.1 → XP_038484998.1  insulin-induced gene 2 protein isoform X1

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  6. XM_038629073.1 → XP_038485001.1  insulin-induced gene 2 protein isoform X4

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 112
    INSIG; Insulin-induced protein (INSIG)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049240.1 Alternate UU_Cfam_GSD_1.0

    Range
    33222123..33242041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038564982.1 → XP_038420910.1  insulin-induced gene 2 protein isoform X2

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 142
    INSIG; Insulin-induced protein (INSIG)

  2. XM_038564979.1 → XP_038420907.1  insulin-induced gene 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMJ2, A0A8C0NZL6, A0A8C0QLG9, A0A8I3MQT8, A0A8I3RUF9
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  3. XM_038564983.1 → XP_038420911.1  insulin-induced gene 2 protein isoform X3

    Conserved Domains (1) summary
    pfam07281
    Location:1 → 103
    INSIG; Insulin-induced protein (INSIG)

  4. XM_038564980.1 → XP_038420908.1  insulin-induced gene 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMJ2, A0A8C0NZL6, A0A8C0QLG9, A0A8I3MQT8, A0A8I3RUF9
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  5. XM_038564981.1 → XP_038420909.1  insulin-induced gene 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMJ2, A0A8C0NZL6, A0A8C0QLG9, A0A8I3MQT8, A0A8I3RUF9
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  6. XM_038564984.1 → XP_038420912.1  insulin-induced gene 2 protein isoform X4

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 112
    INSIG; Insulin-induced protein (INSIG)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006601.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    32063758..32083699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038454694.1 → XP_038310622.1  insulin-induced gene 2 protein isoform X2

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 142
    INSIG; Insulin-induced protein (INSIG)

  2. XM_038454692.1 → XP_038310620.1  insulin-induced gene 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMJ2, A0A8C0NZL6, A0A8C0QLG9, A0A8I3MQT8, A0A8I3RUF9
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  3. XM_038454695.1 → XP_038310623.1  insulin-induced gene 2 protein isoform X3

    Conserved Domains (1) summary
    pfam07281
    Location:1 → 103
    INSIG; Insulin-induced protein (INSIG)

  4. XM_038454693.1 → XP_038310621.1  insulin-induced gene 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMJ2, A0A8C0NZL6, A0A8C0QLG9, A0A8I3MQT8, A0A8I3RUF9
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  5. XM_848012.6 → XP_853105.1  insulin-induced gene 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0KMJ2, A0A8C0NZL6, A0A8C0QLG9, A0A8I3MQT8, A0A8I3RUF9
    Conserved Domains (1) summary
    pfam07281
    Location:31 → 211
    INSIG; Insulin-induced protein (INSIG)

  6. XM_038454696.1 → XP_038310624.1  insulin-induced gene 2 protein isoform X4

    Conserved Domains (1) summary
    pfam07281
    Location:31 → 112
    INSIG; Insulin-induced protein (INSIG)
Nucleotide Protein
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