LHX3 LIM homeobox 3 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: LHX3provided by VGNC
Official Full Name: LIM homeobox 3provided by VGNC
Primary source: VGNC:VGNC:42664
See related: Ensembl:ENSCAFG00845007030
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Annotation information: Annotation category: suggests misassembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	9	NC_051813.1 (50125225..50131690)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	9	NC_006591.4 (48499054..48504456)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	9	NC_049230.1 (49247527..49252929)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	9	NC_049269.1 (48905665..48911059)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	9	NC_049750.1 (49199965..49205359)

Chromosome 9 - NC_051813.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dwarfism in Tibetan Terrier dogs with an LHX3 mutation.
Title: Dwarfism in Tibetan Terrier dogs with an LHX3 mutation.
7 bp deletion in intron 5 is associated with pituitary dwarfism in Saarloos and Czechoslovakian wolfdogs
Title: Pituitary dwarfism in Saarloos and Czechoslovakian wolfdogs is associated with a mutation in LHX3.
These findings suggest an association between the LHX3 mutation in dogs with canine pituitary dwarfism and atlanto-axial malformations.
Title: Atlanto-axial malformation and instability in dogs with pituitary dwarfism due to an LHX3 mutation.
A contraction of a DNA repeat in intron 5 of canine LHX3 leads to deficient splicing and is associated with pituitary dwarfism.
Title: A contracted DNA repeat in LHX3 intron 5 is associated with aberrant splicing and pituitary dwarfism in German shepherd dogs.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: LIM/homeobox protein Lhx3

Names: LIM homeodomain box protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001197187.1 → NP_001184116.1 LIM/homeobox protein Lhx3

See identical proteins and their annotated locations for NP_001184116.1

Status: PROVISIONAL

Source sequence(s)

GQ463737

UniProtKB/TrEMBL

A0A8C0JKM2, A0A8C0LY98, A0A8C0T2C1, A0A8I3MU49, E0X4D7

Related

ENSCAFP00845009762.1, ENSCAFT00845012496.1

Conserved Domains (3) summary

cd09376
Location:95 → 150

LIM2_Lhx3_Lhx4; The second LIM domain of Lhx3-Lhx4 family

cd09467
Location:33 → 87

LIM1_Lhx3b; The first LIM domain of Lhx3b

pfam00046
Location:165 → 219

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051813.1 Reference ROS_Cfam_1.0

Range

50125225..50131690

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038675092.1 → XP_038531020.1 LIM/homeobox protein Lhx3 isoform X1

UniProtKB/TrEMBL

A0A8C0JNR2

Conserved Domains (3) summary

cd09376
Location:66 → 121

LIM2_Lhx3_Lhx4; The second LIM domain of Lhx3-Lhx4 family

cd09467
Location:4 → 58

LIM1_Lhx3b; The first LIM domain of Lhx3b

pfam00046
Location:136 → 190

Homeobox; Homeobox domain