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INPP5E inositol polyphosphate-5-phosphatase E [ Canis lupus familiaris (dog) ]

Gene ID: 607443, updated on 17-Aug-2024

Summary

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Official Symbol
INPP5Eprovided by VGNC
Official Full Name
inositol polyphosphate-5-phosphatase Eprovided by VGNC
Primary source
VGNC:VGNC:42033
See related
Ensembl:ENSCAFG00845005885
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (49937770..49948230)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (48311690..48322149)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (49059986..49070445)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (48718526..48728777)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (49012481..49022941)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene notch receptor 1 Neighboring gene formin-like protein 7 Neighboring gene SEC16 homolog A, endoplasmic reticulum export factor Neighboring gene peptidase, mitochondrial processing subunit alpha Neighboring gene endosome associated trafficking regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A splice site variant in INPP5E causes diffuse cystic renal dysplasia and hepatic fibrosis in dogs. Dillard KJ, et al. PLoS One, 2018. PMID 30235266, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the INPP5E: c.1572+5G>A variant is causal for the ciliopathy in Norwich Terriers.
    Title: A splice site variant in INPP5E causes diffuse cystic renal dysplasia and hepatic fibrosis in dogs.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables inositol-polyphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
72 kDa inositol polyphosphate 5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase type IV
Names
inositol polyphosphate-5-phosphatase, 72 kDa
peptidase (mitochondrial processing) alpha
XP_005625165.1
XP_005625166.1
XP_022279293.1
XP_038342845.1
XP_038342846.1
XP_038342847.1
XP_038404700.1
XP_038404701.1
XP_038404702.1
XP_038468639.1
XP_038468640.1
XP_038468641.1
XP_038533933.1
XP_038533934.1
XP_038533935.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    49937770..49948230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038678006.1 → XP_038533934.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X1

    UniProtKB/TrEMBL
    A0A8C0JLG2, A0A8C0M3F9, A0A8I3N0Y9, A0A8P0NKI7
    Conserved Domains (1) summary
    cd09095
    Location:264 → 562
    INPP5c_INPP5E-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Inositol polyphosphate-5-phosphatase E and related proteins

  2. XM_038678005.1 → XP_038533933.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X1

    UniProtKB/TrEMBL
    A0A8C0JLG2, A0A8C0M3F9, A0A8I3N0Y9, A0A8P0NKI7
    Related
    ENSCAFP00845008096.1, ENSCAFT00845010418.1
    Conserved Domains (1) summary
    cd09095
    Location:264 → 562
    INPP5c_INPP5E-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Inositol polyphosphate-5-phosphatase E and related proteins

  3. XM_038678007.1 → XP_038533935.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X2

    UniProtKB/TrEMBL
    A0A8C0M3F9
    Conserved Domains (1) summary
    cd09095
    Location:264 → 562
    INPP5c_INPP5E-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Inositol polyphosphate-5-phosphatase E and related proteins

RNA

  1. XR_005432580.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    48718526..48728777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038486918.1 → XP_038342846.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X1

  2. XM_038486917.1 → XP_038342845.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X1

  3. XM_038486919.1 → XP_038342847.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X2

RNA

  1. XR_005331118.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    49012481..49022941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038612712.1 → XP_038468640.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X1

    Conserved Domains (1) summary
    cd09095
    Location:264 → 562
    INPP5c_INPP5E-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Inositol polyphosphate-5-phosphatase E and related proteins

  2. XM_038612711.1 → XP_038468639.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X1

    Conserved Domains (1) summary
    cd09095
    Location:264 → 562
    INPP5c_INPP5E-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Inositol polyphosphate-5-phosphatase E and related proteins

  3. XM_038612713.1 → XP_038468641.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X2

    Conserved Domains (1) summary
    cd09095
    Location:264 → 562
    INPP5c_INPP5E-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Inositol polyphosphate-5-phosphatase E and related proteins

RNA

  1. XR_005399236.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    49059986..49070445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038548773.1 → XP_038404701.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X1

    UniProtKB/TrEMBL
    A0A8C0JLG2, A0A8C0M3F9, A0A8I3N0Y9, A0A8P0NKI7
    Conserved Domains (1) summary
    cd09095
    Location:264 → 562
    INPP5c_INPP5E-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Inositol polyphosphate-5-phosphatase E and related proteins

  2. XM_038548772.1 → XP_038404700.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X1

    UniProtKB/TrEMBL
    A0A8C0JLG2, A0A8C0M3F9, A0A8I3N0Y9, A0A8P0NKI7
    Conserved Domains (1) summary
    cd09095
    Location:264 → 562
    INPP5c_INPP5E-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Inositol polyphosphate-5-phosphatase E and related proteins

  3. XM_038548774.1 → XP_038404702.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X2

    UniProtKB/TrEMBL
    A0A8C0M3F9
    Conserved Domains (1) summary
    cd09095
    Location:264 → 562
    INPP5c_INPP5E-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Inositol polyphosphate-5-phosphatase E and related proteins

RNA

  1. XR_005364805.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    48311690..48322149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005625109.3 → XP_005625166.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X1

    See identical proteins and their annotated locations for XP_005625166.1

    UniProtKB/TrEMBL
    A0A8C0JLG2, A0A8C0M3F9, A0A8I3N0Y9, A0A8P0NKI7
    Conserved Domains (1) summary
    cd09095
    Location:264 → 562
    INPP5c_INPP5E-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Inositol polyphosphate-5-phosphatase E and related proteins

  2. XM_005625108.4 → XP_005625165.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X1

    See identical proteins and their annotated locations for XP_005625165.1

    UniProtKB/TrEMBL
    A0A8C0JLG2, A0A8C0M3F9, A0A8I3N0Y9, A0A8P0NKI7
    Conserved Domains (1) summary
    cd09095
    Location:264 → 562
    INPP5c_INPP5E-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Inositol polyphosphate-5-phosphatase E and related proteins

  3. XM_022423585.2 → XP_022279293.1  phosphatidylinositol polyphosphate 5-phosphatase type IV isoform X2

    UniProtKB/TrEMBL
    A0A8C0M3F9
    Conserved Domains (1) summary
    cd09095
    Location:264 → 562
    INPP5c_INPP5E-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Inositol polyphosphate-5-phosphatase E and related proteins

RNA

  1. XR_005400327.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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