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Ltbp1 latent transforming growth factor beta binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59107, updated on 17-Aug-2024

Summary

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Official Symbol
Ltbp1provided by RGD
Official Full Name
latent transforming growth factor beta binding protein 1provided by RGD
Primary source
RGD:68379
See related
EnsemblRapid:ENSRNOG00000033090 AllianceGenome:RGD:68379
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable microfibril binding activity and transforming growth factor beta binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and cellular response to platelet-derived growth factor stimulus. Located in several cellular components, including dendrite; neuronal cell body; and perinuclear region of cytoplasm. Part of large latent transforming growth factor-beta complex. Biomarker of glomerulonephritis and transient cerebral ischemia. Human ortholog(s) of this gene implicated in cutis laxa. Orthologous to human LTBP1 (latent transforming growth factor beta binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 310.7), Lung (RPKM 206.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q13
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (25781625..26177346, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (20029629..20425339, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (21203502..21600441, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 98, member A Neighboring gene RAS guanyl releasing protein 3 Neighboring gene ribosomal protein L32, pseudogene 18 Neighboring gene uncharacterized LOC120103479 Neighboring gene 40S ribosomal protein S18 pseudogene Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Parathyroid hormone stimulation and PKA signaling of latent transforming growth factor-beta binding protein-1 (LTBP-1) mRNA expression in osteoblastic cells. Kwok S, et al. J Cell Biochem, 2005 Aug 1. PMID 15880704
  2. The first stage of transforming growth factor beta1 activation is release of the large latent complex from the extracellular matrix of growth plate chondrocytes by matrix vesicle stromelysin-1 (MMP-3). Maeda S, et al. Calcif Tissue Int, 2002 Jan. PMID 11907708
  3. Beta(2)-adrenoceptor stimulation enhances latent transforming growth factor-beta-binding protein-1 and transforming growth factor-beta1 expression in rat hippocampus after transient forebrain ischemia. Zhu Y, et al. Neuroscience, 2001. PMID 11720783
  4. Vitamin D3 metabolites regulate LTBP1 and latent TGF-beta1 expression and latent TGF-beta1 incorporation in the extracellular matrix of chondrocytes. Pedrozo HA, et al. J Cell Biochem, 1999 Jan 1. PMID 10025676
  5. Subcellular localization of (latent) transforming growth factor beta and the latent TGF-beta binding protein in rat hepatocytes and hepatic stellate cells. Roth-Eichhorn S, et al. Hepatology, 1998 Dec. PMID 9828223

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LTBP-1 but not TGF-beta1 is induced by PDGF-BB and TGF-beta1 autoinduction does not affect the expression of LTBP-beta1
    Title: PDGF-BB induces expression of LTBP-1 but not TGF-beta1 in a rat cirrhotic fat storing cell line.
  2. Mesangial expression of LTBP-1 and fibrillin-1 is induced early in experimental nephritis and LTBP-1 and fibrillin-1 are partially colocalized in the nephritic glomerulus.
    Title: Induction and coexpression of latent transforming growth factor beta-binding protein-1 and fibrillin-1 in experimental glomerulonephritis.
  3. fibronectin has a role in LTBP1 assembly in the ECM and in regulation of TGF beta via LTBP1 interactions
    Title: Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1.
  4. observations suggest that latent transforming growth factor-beta binding protein-1 plays a critical role in intimal thickening of diabetic artery through the acceleration of smooth muscle cell migration via integrin-beta(3)
    Title: Latent transforming growth factor-beta binding protein-1, a component of latent transforming growth factor-beta complex, accelerates the migration of aortic smooth muscle cells in diabetic rats through integrin-beta3.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microfibril binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfibril binding IEA
Inferred from Electronic Annotation
more info
  
enables microfibril binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables receptor ligand inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables receptor ligand inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transforming growth factor beta binding IEA
Inferred from Electronic Annotation
more info
  
enables transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aorta development ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to parathyroid hormone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to platelet-derived growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to vitamin D IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within coronary vasculature development ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of protein localization to extracellular region ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sequestering of TGFbeta in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
involved_in sequestering of TGFbeta in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
involved_in sequestering of TGFbeta in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within ventricular septum development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of large latent transforming growth factor-beta complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microfibril IEA
Inferred from Electronic Annotation
more info
  
located_in microfibril ISO
Inferred from Sequence Orthology
more info
  
located_in microfibril ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
latent-transforming growth factor beta-binding protein 1
Names
LTBP-1
LanC (bacterial lantibiotic synthetase component C)-like 1
TGF-beta-1-BP-1
transforming growth factor beta-1-binding protein 1
transforming growth factor beta-1-masking protein large subunit
transforming growth factor-beta (TGF-beta) masking protein large subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021587.2 → NP_067598.2  latent-transforming growth factor beta-binding protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q00918
    UniProtKB/TrEMBL
    A6H9X2, D3ZAA3
    Related
    ENSRNOP00000040099.4, ENSRNOT00000047674.6
    Conserved Domains (6) summary
    smart00179
    Location:1194 → 1235
    EGF_CA; Calcium-binding EGF-like domain
    PHA03247
    Location:703 → 860
    PHA03247; large tegument protein UL36; Provisional
    cd00054
    Location:990 → 1023
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:907 → 947
    EGF_CA; Calcium-binding EGF domain
    pfam00683
    Location:681 → 722
    TB; TB domain
    pfam12662
    Location:888 → 910
    cEGF; Complement Clr-like EGF-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    25781625..26177346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262385.1 → XP_063118455.1  latent-transforming growth factor beta-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q00918
    UniProtKB/TrEMBL
    A0A8I6AA33
    Related
    ENSRNOP00000088104.1, ENSRNOT00000101612.2

  2. XM_063262388.1 → XP_063118458.1  latent-transforming growth factor beta-binding protein 1 isoform X4

    UniProtKB/Swiss-Prot
    Q00918

  3. XM_063262387.1 → XP_063118457.1  latent-transforming growth factor beta-binding protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q00918
    UniProtKB/TrEMBL
    A0A8I5Y739
    Related
    ENSRNOP00000078120.1, ENSRNOT00000112287.2

  4. XM_063262386.1 → XP_063118456.1  latent-transforming growth factor beta-binding protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q00918

  5. XM_063262389.1 → XP_063118459.1  latent-transforming growth factor beta-binding protein 1 isoform X5

    UniProtKB/Swiss-Prot
    Q00918

  6. XM_063262390.1 → XP_063118460.1  latent-transforming growth factor beta-binding protein 1 isoform X6

  7. XM_063262393.1 → XP_063118463.1  latent-transforming growth factor beta-binding protein 1 isoform X9

  8. XM_063262392.1 → XP_063118462.1  latent-transforming growth factor beta-binding protein 1 isoform X8

  9. XM_063262391.1 → XP_063118461.1  latent-transforming growth factor beta-binding protein 1 isoform X7

    UniProtKB/Swiss-Prot
    Q00918
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00918.1 GenPept UniProtKB/Swiss-Prot:Q00918

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