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PTPRM protein tyrosine phosphatase, receptor type M [ Homo sapiens (human) ]

Gene ID: 5797, updated on 12-May-2016
Official Symbol
PTPRMprovided by HGNC
Official Full Name
protein tyrosine phosphatase, receptor type Mprovided by HGNC
Primary source
HGNC:HGNC:9675
See related
Ensembl:ENSG00000173482 HPRD:01479; MIM:176888; Vega:OTTHUMG00000131575
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Orthologs
Location:
18p11.2
Exon count:
43
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 18 NC_000018.10 (7567316..8406861)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (7567314..8406859)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371975 Neighboring gene uncharacterized LOC105371976 Neighboring gene uncharacterized LOC100192426 Neighboring gene ring finger and WD repeat domain 2, E3 ubiquitin protein ligase pseudogene 1 Neighboring gene thymocyte selection associated family member 3, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation.
NHGRI GWA Catalog
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
NHGRI GWA Catalog
  • Adherens junction, organism-specific biosystem (from KEGG)
    Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junction, conserved biosystem (from KEGG)
    Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Nectin adhesion pathway, organism-specific biosystem (from Pathway Interaction Database)
    Nectin adhesion pathway, organism-specific biosystem
    Nectin adhesion pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC166994

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasodilation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
retina layer formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
retinal ganglion cell axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
receptor-type tyrosine-protein phosphatase mu
Names
protein tyrosine phosphatase mu
protein tyrosine phosphatase, receptor type, M
protein tyrosine phosphatase, receptor type, mu polypeptide
protein-tyrosine phosphatase mu
NP_001098714.1
NP_002836.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105244.1NP_001098714.1  receptor-type tyrosine-protein phosphatase mu isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC151842, BF725297, BQ926672, DC381904, X58288
    Consensus CDS
    CCDS58613.1
    UniProtKB/Swiss-Prot
    P28827
    Related
    ENSP00000463325, OTTHUMP00000260261, ENST00000580170, OTTHUMT00000443793
    Conserved Domains (7) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9121166
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00047
    Location:9391166
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:199261
    ig; Immunoglobulin domain
  2. NM_002845.3NP_002836.3  receptor-type tyrosine-protein phosphatase mu isoform 2 precursor

    See identical proteins and their annotated locations for NP_002836.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two adjacent in-frame exons in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC151842, BF725297, BQ926672, DC381904, X58288
    Consensus CDS
    CCDS11840.1
    UniProtKB/Swiss-Prot
    P28827
    Related
    ENSP00000331418, OTTHUMP00000162329, ENST00000332175, OTTHUMT00000254456
    Conserved Domains (7) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8991153
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00047
    Location:9261153
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:199261
    ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p2 Primary Assembly

    Range
    7567316..8406861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525708.1XP_011524010.1  

    Conserved Domains (7) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9371208
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00047
    Location:9641208
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:199261
    ig; Immunoglobulin domain
  2. XM_011525710.1XP_011524012.1  

    Conserved Domains (7) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9371191
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00047
    Location:9641191
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:199261
    ig; Immunoglobulin domain
  3. XM_011525709.1XP_011524011.1  

    Conserved Domains (7) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9331204
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00047
    Location:9601204
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:199261
    ig; Immunoglobulin domain
  4. XM_011525711.1XP_011524013.1  

    Conserved Domains (7) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9331187
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00047
    Location:9601187
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:199261
    ig; Immunoglobulin domain
  5. XM_006722335.2XP_006722398.1  

    Conserved Domains (7) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9241195
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00047
    Location:9511195
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:199261
    ig; Immunoglobulin domain
  6. XM_011525712.1XP_011524014.1  

    Conserved Domains (7) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9121183
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00047
    Location:9391183
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:199261
    ig; Immunoglobulin domain
  7. XM_006722337.2XP_006722400.1  

    Conserved Domains (7) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8991170
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00047
    Location:9261170
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:199261
    ig; Immunoglobulin domain
  8. XM_011525719.1XP_011524021.1  

    Conserved Domains (5) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:199261
    ig; Immunoglobulin domain
  9. XM_011525718.1XP_011524020.1  

    Conserved Domains (5) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:199261
    ig; Immunoglobulin domain
  10. XM_011525721.1XP_011524023.1  

    Conserved Domains (5) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:199261
    ig; Immunoglobulin domain
  11. XM_011525720.1XP_011524022.1  

    Conserved Domains (5) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:199261
    ig; Immunoglobulin domain
  12. XM_011525713.1XP_011524015.1  

    Conserved Domains (7) summary
    cd06263
    Location:1120
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:1120
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8751146
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:130216
    IG_like; Immunoglobulin like
    cd00047
    Location:9021146
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:437519
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:137199
    ig; Immunoglobulin domain
  13. XM_011525714.1XP_011524016.1  

    Conserved Domains (7) summary
    cd06263
    Location:1114
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:1114
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8691140
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:124210
    IG_like; Immunoglobulin like
    cd00047
    Location:8961140
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:431513
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:131193
    ig; Immunoglobulin domain
  14. XM_011525715.1XP_011524017.1  

    Conserved Domains (3) summary
    smart00194
    Location:724995
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:751995
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:286368
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  15. XM_011525722.1XP_011524024.1  

    See identical proteins and their annotated locations for XP_011524024.1

    Conserved Domains (3) summary
    smart00194
    Location:699953
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:726953
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:286368
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  16. XM_011525716.1XP_011524018.1  

    See identical proteins and their annotated locations for XP_011524018.1

    Conserved Domains (3) summary
    smart00194
    Location:686940
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:713940
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:286368
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  17. XM_011525717.1XP_011524019.1  

    Conserved Domains (3) summary
    smart00194
    Location:558829
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:585829
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:120202
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. XR_430046.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    7567289..8407034
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    GenBank, FASTA, Sequence Viewer (Graphics)