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CG34357 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740349, updated on 18-Sep-2024

Summary

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Official Symbol
CG34357provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0085386
Locus tag
Dmel_CG34357
See related
AllianceGenome:FB:FBgn0085386
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12584; CG12585; CG14652; cg34357; CG41467; CG9783; Dmel\CG34357; GYC
Old locus tag
CG12585; CG14652; CG41467; CG9783; Dmel_CG12585; Dmel_CG14652; Dmel_CG41467; Dmel_CG9783
Summary
Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process; cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa. Orthologous to human GUCY2D (guanylate cyclase 2D, retinal) and GUCY2F (guanylate cyclase 2F, retinal). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
82B4-82C2; 3-47.1 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4491943..4558067, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (317665..383789, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene sterile affecting ciliogenesis Neighboring gene Factor interacting with poly(A) polymerase 1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR31526 Neighboring gene Mucin related 82C Neighboring gene long non-coding RNA:CR45558 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions. Biswas KH, et al. J Mol Evol, 2009 Jun. PMID 19495554
  2. Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor. Miozzo F, et al. Nat Commun, 2022 Mar 17. PMID 35301315, Free PMC Article
  3. Evolutionary Dynamics of Abundant Stop Codon Readthrough. Jungreis I, et al. Mol Biol Evol, 2016 Dec. PMID 27604222, Free PMC Article
  4. The mRNA transportome of the BicD/Egl transport machinery. Vazquez-Pianzola P, et al. RNA Biol, 2017 Jan 2. PMID 27801632, Free PMC Article
  5. Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease. Huichalaf CH, et al. Hum Mol Genet, 2019 Jun 15. PMID 30753434, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c4501572-4497904 mobile_element_type = transposon:Fw2{}4362
  • Loc: c4501896-4501783 mobile_element_type = transposon:INE-1{}3829
  • Loc: c4504433-4504139 mobile_element_type = transposon:INE-1{}3831
  • Loc: c4507781-4506702 mobile_element_type = transposon:jockey2{}1193
  • Loc: c4516736-4515245 mobile_element_type = transposon:HB{}1194
  • Loc: c4518848-4518538 mobile_element_type = transposon:S{}1196
  • Loc: c4525779-4525091 mobile_element_type = transposon:Bari2{}4359
  • Loc: c4540133-4538934 mobile_element_type = transposon:1360{}1198
  • Loc: c4548312-4548087 mobile_element_type = transposon:INE-1{}3864
  • Loc: c4553265-4553105 mobile_element_type = transposon:INE-1{}3866
  • Loc: c4556140-4555709 mobile_element_type = transposon:INE-1{}4383

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cGMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG34357-PB
CG34357-PC
CG34357-PD
CG34357-PE
NP_001097681.2
NP_001097682.1
NP_001189166.1
NP_001356914.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    4491943..4558067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104211.2 → NP_001097681.2  uncharacterized protein Dmel_CG34357, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097681.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JQT1
    Conserved Domains (5) summary
    smart00044
    Location:1074 → 1266
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:1101 → 1286
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07701
    Location:1052 → 1095
    HNOBA; Heme NO binding associated
    pfam07714
    Location:777 → 1035
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:763 → 1041
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001370010.1 → NP_001356914.1  uncharacterized protein Dmel_CG34357, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4D6K026
    Conserved Domains (2) summary
    smart00044
    Location:1074 → 1266
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cl21453
    Location:763 → 1041
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001202237.2 → NP_001189166.1  uncharacterized protein Dmel_CG34357, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189166.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JQT1
    Conserved Domains (5) summary
    smart00044
    Location:1074 → 1266
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:1101 → 1286
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07701
    Location:1052 → 1095
    HNOBA; Heme NO binding associated
    pfam07714
    Location:777 → 1035
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:763 → 1041
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001104212.2 → NP_001097682.1  uncharacterized protein Dmel_CG34357, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097682.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0IGY5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A4D6K026 A0A4D6K026
A8JQT1 A8JQT1
Q0IGY5 Q0IGY5

Gene LinkOut

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