U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

stxbp5b syntaxin binding protein 5b (tomosyn) [ Danio rerio (zebrafish) ]

Gene ID: 571925, updated on 17-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
stxbp5bprovided by ZNC
Official Full Name
syntaxin binding protein 5b (tomosyn)provided by ZNC
Primary source
ZFIN:ZDB-GENE-090821-5
See related
Ensembl:ENSDARG00000029234 AllianceGenome:ZFIN:ZDB-GENE-090821-5
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Predicted to be involved in regulation of exocytosis and regulation of protein secretion. Predicted to act upstream of or within exocytosis. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human STXBP5 (syntaxin binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 17
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (7232297..7351434, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (7075088..7194291, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uronyl 2-sulfotransferase Neighboring gene SAM and SH3 domain containing 1b Neighboring gene RAB32b, member RAS oncogene family Neighboring gene glutamate receptor, metabotropic 1b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. Coppola U, et al. BMC Evol Biol, 2016 Jan 27. PMID 26818140, Free PMC Article
  2. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin II binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
syntaxin-binding protein 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    7232297..7351434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158604.5 → XP_005158661.1  syntaxin-binding protein 5 isoform X7

    UniProtKB/TrEMBL
    A0A8M2B5G8
    Related
    ENSDARP00000089501.4, ENSDART00000098731.6
    Conserved Domains (5) summary
    COG2319
    Location:58 → 279
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1041 → 1101
    R-SNARE_STXBP5; SNARE domain of STXBP5
    pfam08366
    Location:288 → 395
    LLGL; LLGL2
    sd00039
    Location:73 → 106
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:73 → 280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_068214518.1 → XP_068070619.1  syntaxin-binding protein 5 isoform X4

  3. XM_068214517.1 → XP_068070618.1  syntaxin-binding protein 5 isoform X3

  4. XM_068214516.1 → XP_068070617.1  syntaxin-binding protein 5 isoform X2

  5. XM_009292824.4 → XP_009291099.1  syntaxin-binding protein 5 isoform X6

    UniProtKB/TrEMBL
    A0A8M3AR50
    Conserved Domains (5) summary
    COG2319
    Location:58 → 279
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1069 → 1129
    R-SNARE_STXBP5; SNARE domain of STXBP5
    pfam08366
    Location:288 → 395
    LLGL; LLGL2
    sd00039
    Location:73 → 106
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:73 → 280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_009292823.4 → XP_009291098.1  syntaxin-binding protein 5 isoform X5

    UniProtKB/TrEMBL
    A0A8M3AU07
    Conserved Domains (5) summary
    COG2319
    Location:58 → 279
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1084 → 1144
    R-SNARE_STXBP5; SNARE domain of STXBP5
    pfam08366
    Location:288 → 395
    LLGL; LLGL2
    sd00039
    Location:73 → 106
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:73 → 280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_068214515.1 → XP_068070616.1  syntaxin-binding protein 5 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools