smyd2b SET and MYND domain containing 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: smyd2bprovided by ZNC
Official Full Name: SET and MYND domain containing 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041001-201
See related: Ensembl:ENSDARG00000005629 AllianceGenome:ZFIN:ZDB-GENE-041001-201
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:136609; si:dkey-121j17.3
Summary: Predicted to enable RNA polymerase II complex binding activity and histone methyltransferase activity (H3-K36 specific). Acts upstream of or within heart contraction and heart development. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in muscle cell and somite. Orthologous to human SMYD2 (SET and MYND domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (571793..590012)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (582220..600165)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA polymerase II complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K36 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K4 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-lysine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-lysine N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart contraction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA damage response, signal transduction by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: N-lysine methyltransferase SMYD2-B

Names: SET and MYND domain-containing protein 2B; histone methyltransferase SMYD2-B

NP_001025394.1

EC 2.1.1.354

NP_001038756.1

EC 2.1.1.354

XP_005164480.1

EC 2.1.1.354

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030223.1 → NP_001025394.1 N-lysine methyltransferase SMYD2-B isoform 1

Status: PROVISIONAL

Source sequence(s)

BX855610

UniProtKB/TrEMBL

A0A8M1N7E6, T1ECS2

Related

ENSDARP00000005268.7, ENSDART00000028062.10

Conserved Domains (3) summary

pfam00856
Location:205 → 241

SET; SET domain

pfam01753
Location:53 → 91

zf-MYND; MYND finger

pfam13424
Location:342 → 417

TPR_12; Tetratricopeptide repeat
NM_001045291.1 → NP_001038756.1 N-lysine methyltransferase SMYD2-B isoform 2

See identical proteins and their annotated locations for NP_001038756.1

Status: PROVISIONAL

Source sequence(s)

BC116606

UniProtKB/Swiss-Prot

Q5RGL7

Related

ENSDARP00000036459.5, ENSDART00000031759.6

Conserved Domains (3) summary

pfam00856
Location:194 → 230

SET; SET domain

pfam01753
Location:53 → 91

zf-MYND; MYND finger

pfam13424
Location:328 → 403

TPR_12; Tetratricopeptide repeat