U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

klhl3 kelch-like family member 3 [ Danio rerio (zebrafish) ]

Gene ID: 568556, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
klhl3provided by ZNC
Official Full Name
kelch-like family member 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-120203-4
See related
Ensembl:ENSDARG00000056647 AllianceGenome:ZFIN:ZDB-GENE-120203-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable actin binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; distal tubule morphogenesis; and renal sodium ion absorption. Predicted to be located in cytosol. Predicted to be part of Cul3-RING ubiquitin ligase complex. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human KLHL3 (kelch like family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See klhl3 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (24283932..24303185)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (23986701..24005320)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107195253 Neighboring gene D4, zinc and double PHD fingers family 2, like Neighboring gene heterogeneous nuclear ribonucleoprotein A0a Neighboring gene family with sequence similarity 13 member B Neighboring gene uncharacterized LOC110438987

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin. Feiner N, et al. Genome Biol Evol, 2013. PMID 23843192, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
kelch-like protein 3
Names
kelch-like 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001423975.1 → NP_001410904.1  kelch-like protein 3

    Status: VALIDATED

    Source sequence(s)
    BX005228
    UniProtKB/TrEMBL
    A0A8N7T6Q3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    24283932..24303185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009291059.3 → XP_009289334.1  kelch-like protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PUC3
    Related
    ENSDARP00000142614.1, ENSDART00000172868.2
    Conserved Domains (2) summary
    PHA03098
    Location:51 → 567
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:385 → 428
    Kelch; KELCH repeat [structural motif]

  2. XM_691888.7 → XP_696980.1  kelch-like protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A0H2UJ99
    Conserved Domains (2) summary
    PHA03098
    Location:51 → 567
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:385 → 428
    Kelch; KELCH repeat [structural motif]

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394909.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    251979..271343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021472784.1 → XP_021328459.1  kelch-like protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PUC3
    Conserved Domains (2) summary
    PHA03098
    Location:51 → 567
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:385 → 428
    Kelch; KELCH repeat [structural motif]

  2. XM_021472785.1 → XP_021328460.1  kelch-like protein 3 isoform X2

    Conserved Domains (2) summary
    PHA03098
    Location:51 → 567
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:385 → 428
    Kelch; KELCH repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E7F6F9.1 GenPept UniProtKB/Swiss-Prot:E7F6F9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous