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si:ch211-45c16.2 si:ch211-45c16.2 [ Danio rerio (zebrafish) ]

Gene ID: 568412, updated on 11-Apr-2024

Summary

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Official Symbol
si:ch211-45c16.2provided by ZNC
Official Full Name
si:ch211-45c16.2provided by ZNC
Primary source
ZFIN:ZDB-GENE-081105-15
See related
Ensembl:ENSDARG00000009493 AllianceGenome:ZFIN:ZDB-GENE-081105-15
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable JUN kinase kinase kinase activity. Predicted to be involved in JNK cascade. Predicted to act upstream of or within protein autophosphorylation. Orthologous to human MAP3K13 (mitogen-activated protein kinase kinase kinase 13). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 9
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (52694294..52814276, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (53154938..53274749, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110440054 Neighboring gene phosphofructokinase, liver a Neighboring gene uncharacterized LOC101884915 Neighboring gene transient receptor potential cation channel, subfamily M, member 2 Neighboring gene uncharacterized LOC108191349 Neighboring gene interleukin 1 receptor-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The MAP3Ks DLK and LZK Direct Diverse Responses to Axon Damage in Zebrafish Peripheral Neurons. Adula KP, et al. J Neurosci, 2022 Aug 10. PMID 35840323, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 13
XP_017213349.1
XP_017213350.1
XP_021327882.1
XP_021327883.1
XP_021327884.1
XP_021334730.1
XP_696830.5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    52694294..52814276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_691738.9 → XP_696830.5  mitogen-activated protein kinase kinase kinase 13 isoform X2

    UniProtKB/TrEMBL
    A0A8N7UVK5, F6NJB9
    Related
    ENSDARP00000120489.1, ENSDART00000140771.2
    Conserved Domains (1) summary
    cd14059
    Location:225 → 461
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

  2. XM_017357860.2 → XP_017213349.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z2U3, E7FH13
    Related
    ENSDARP00000009159.8, ENSDART00000007401.9
    Conserved Domains (1) summary
    cd14059
    Location:226 → 462
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

  3. XM_017357861.2 → XP_017213350.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z2U3, E7FH13
    Conserved Domains (1) summary
    cd14059
    Location:226 → 462
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

  4. XM_021479055.1 → XP_021334730.1  mitogen-activated protein kinase kinase kinase 13 isoform X3

    UniProtKB/TrEMBL
    A0A8M9QKF0
    Conserved Domains (1) summary
    cd14059
    Location:226 → 462
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394762.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    2440..140595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021472209.1 → XP_021327884.1  mitogen-activated protein kinase kinase kinase 13 isoform X2

    UniProtKB/TrEMBL
    A0A8N7UVK5, F6NJB9
    Conserved Domains (1) summary
    cd14059
    Location:225 → 461
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

  2. XM_021472207.1 → XP_021327882.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z2U3, E7FH13
    Conserved Domains (1) summary
    cd14059
    Location:226 → 462
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

  3. XM_021472208.1 → XP_021327883.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z2U3, E7FH13
    Conserved Domains (1) summary
    cd14059
    Location:226 → 462
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
Nucleotide Protein Strain
Heading Accession and Version

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