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sv2a synaptic vesicle glycoprotein 2A [ Danio rerio (zebrafish) ]

Gene ID: 568033, updated on 25-Apr-2024

Summary

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Official Symbol
sv2aprovided by ZNC
Official Full Name
synaptic vesicle glycoprotein 2Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-131001-1
See related
Ensembl:ENSDARG00000059945 AllianceGenome:ZFIN:ZDB-GENE-131001-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-271d10.3
Summary
Predicted to enable transmembrane transporter activity. Predicted to act upstream of or within chemical synaptic transmission; neurotransmitter transport; and transmembrane transport. Predicted to be located in cytoplasmic vesicle; membrane; and synapse. Predicted to be integral component of membrane. Orthologous to human SV2A (synaptic vesicle glycoprotein 2A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See sv2a in Genome Data Viewer
Location:
chromosome: 16
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (46111992..46202706)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (46145279..46229850)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene OTU deubiquitinase 7B Neighboring gene myotubularin related protein 11 Neighboring gene uncharacterized LOC110438002 Neighboring gene bolA family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Connectivity Mapping Using a Novel sv2a Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery. Zhang Y, et al. Front Mol Neurosci, 2022. PMID 35686059, Free PMC Article
  2. Testicular transcriptome alterations in zebrafish (Danio rerio) exposure to 17β-estradiol. Zheng Y, et al. Chemosphere, 2019 Mar. PMID 30465971
  3. Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia. Pan W, et al. Sci Rep, 2022 Jun 16. PMID 35710785, Free PMC Article
  4. Evolution of vertebrate nicotinic acetylcholine receptors. Pedersen JE, et al. BMC Evol Biol, 2019 Jan 30. PMID 30700248, Free PMC Article
  5. Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity. Cosacak MI, et al. Cell Rep, 2019 Apr 23. PMID 31018142

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuronal action potential propagation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within swimming behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
synaptic vesicle glycoprotein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    46111992..46202706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_691342.7 → XP_696434.2  synaptic vesicle glycoprotein 2A

    UniProtKB/TrEMBL
    A0A8N7T8D0, E7F6Z2
    Related
    ENSDARP00000139043.1, ENSDART00000172232.2
    Conserved Domains (2) summary
    cd06174
    Location:162 → 725
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR01299
    Location:1 → 733
    synapt_SV2; synaptic vesicle protein SV2
Nucleotide Protein Strain
Heading Accession and Version

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