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serac1 serine active site containing 1 [ Danio rerio (zebrafish) ]

Gene ID: 568022, updated on 11-Apr-2024

Summary

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Official Symbol
serac1provided by ZNC
Official Full Name
serine active site containing 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040616-1
See related
Ensembl:ENSDARG00000056121 AllianceGenome:ZFIN:ZDB-GENE-040616-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be located in endoplasmic reticulum; membrane; and mitochondrion. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome. Orthologous to human SERAC1 (serine active site containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See serac1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (26048303..26060260, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (26149214..26161101, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:dkey-12h9.6 Neighboring gene general transcription factor IIH, polypeptide 5 Neighboring gene uncharacterized LOC110438180 Neighboring gene myc target 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein SERAC1
Names
serine active site-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030286.1 → NP_001025457.1  protein SERAC1

    Status: PROVISIONAL

    Source sequence(s)
    AL954831
    UniProtKB/TrEMBL
    A0A8M1N7H8
    Conserved Domains (2) summary
    cd00020
    Location:220 → 304
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:187 → 215
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    26048303..26060260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468494.1 → XP_021324169.1  protein SERAC1 isoform X1

    UniProtKB/Swiss-Prot
    Q5SNQ7, Q5SNQ8
    UniProtKB/TrEMBL
    A0A8M9PSW7
    Conserved Domains (1) summary
    sd00043
    Location:259 → 287
    ARM; armadillo repeat [structural motif]

  2. XM_021468495.1 → XP_021324170.1  protein SERAC1 isoform X1

    UniProtKB/Swiss-Prot
    Q5SNQ7, Q5SNQ8
    UniProtKB/TrEMBL
    A0A8M9PSW7
    Conserved Domains (1) summary
    sd00043
    Location:259 → 287
    ARM; armadillo repeat [structural motif]

  3. XM_005160583.4 → XP_005160640.1  protein SERAC1 isoform X1

    See identical proteins and their annotated locations for XP_005160640.1

    UniProtKB/Swiss-Prot
    Q5SNQ7, Q5SNQ8
    UniProtKB/TrEMBL
    A0A8M9PSW7
    Related
    ENSDARP00000126448.1, ENSDART00000151950.3
    Conserved Domains (1) summary
    sd00043
    Location:259 → 287
    ARM; armadillo repeat [structural motif]

  4. XM_021468496.1 → XP_021324171.1  protein SERAC1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PPI6
    Conserved Domains (1) summary
    sd00043
    Location:259 → 284
    ARM; armadillo repeat [structural motif]

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395074.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    163685..175170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SNQ7.1 GenPept UniProtKB/Swiss-Prot:Q5SNQ7

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