mthfd1a methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1a, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mthfd1aprovided by ZNC
Official Full Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1a, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041001-127
See related: Ensembl:ENSDARG00000018266 AllianceGenome:ZFIN:ZDB-GENE-041001-127
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-1h6.1
Summary: Predicted to enable methenyltetrahydrofolate cyclohydrolase activity and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to act upstream of or within one-carbon metabolic process. Predicted to be active in cytosol. Is expressed in anterior neural tube and optic cup. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; cleft lip; developmental cardiac valvular defect; neural tube defect (multiple); and tetralogy of Fallot. Orthologous to human MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (27646612..27682828)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (27747705..27783742)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that upregulation of 10-formyltetrahydrofolate dehydrogenase (FDH) involving CEBPalpha helps relieve embryonic oxidative stress induced by ethanol exposure.
Title: Ethanol-induced upregulation of 10-formyltetrahydrofolate dehydrogenase helps relieve ethanol-induced oxidative stress.

Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables formate-tetrahydrofolate ligase activity	IEA Inferred from Electronic Annotation more info
enables methenyltetrahydrofolate cyclohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methenyltetrahydrofolate cyclohydrolase activity	IEA Inferred from Electronic Annotation more info
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolate interconversion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-1-tetrahydrofolate synthase, cytoplasmic

Names: MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

27646612..27682828

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017352710.2 → XP_017208199.1 C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

UniProtKB/TrEMBL

A0A2R8Q1M2, A0A8M6YUD7

Related

ENSDARP00000146429.1, ENSDART00000185628.1

Conserved Domains (2) summary

COG0190
Location:50 → 302

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

cd00477
Location:340 → 884

FTHFS; Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2 ...
XM_690886.8 → XP_695978.4 C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

UniProtKB/TrEMBL

A0A8M9PW61, Q5RIH2

Related

ENSDARP00000120805.2, ENSDART00000141697.3

Conserved Domains (2) summary

COG0190
Location:26 → 315

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

cd00477
Location:353 → 897

FTHFS; Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2 ...

RNA

XR_002456228.1 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018395075.1 Reference GRCz11 ALT_DRER_TU_1

Range

73525..109741

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021473375.1 → XP_021329050.1 C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

UniProtKB/TrEMBL

A0A2R8Q1M2, A0A8M6YUD7

Conserved Domains (2) summary

COG0190
Location:50 → 302

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

cd00477
Location:340 → 884

FTHFS; Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2 ...
XM_021473374.1 → XP_021329049.1 C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

UniProtKB/TrEMBL

A0A8M9PW61, Q5RIH2

Conserved Domains (2) summary

COG0190
Location:26 → 315

FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

cd00477
Location:353 → 897

FTHFS; Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2 ...