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kmt2bb lysine (K)-specific methyltransferase 2Bb [ Danio rerio (zebrafish) ]

Gene ID: 566825, updated on 27-Mar-2024

Summary

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Official Symbol
kmt2bbprovided by ZNC
Official Full Name
lysine (K)-specific methyltransferase 2Bbprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080521-1
See related
Ensembl:ENSDARG00000060697 AllianceGenome:ZFIN:ZDB-GENE-080521-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mll4b
Summary
Predicted to enable histone methyltransferase activity (H3-K4 specific). Predicted to be involved in histone H3-K4 methylation and positive regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization and methylation. Predicted to be located in nucleus. Predicted to be part of histone methyltransferase complex. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; dystonia; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See kmt2bb in Genome Data Viewer
Location:
chromosome: 15
Exon count:
37
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (37457008..37543667, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (37555423..37642074, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene potassium inwardly rectifying channel subfamily J member 20 Neighboring gene IGF-like family receptor 1 Neighboring gene presenilin enhancer, gamma-secretase subunit Neighboring gene heat shock protein, alpha-crystallin-related, b6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The DEAD-box RNA helicase Ddx39ab is essential for myocyte and lens development in zebrafish. Zhang L, et al. Development, 2018 Apr 23. PMID 29636379
  2. Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes. Sun XJ, et al. PLoS One, 2008 Jan 30. PMID 18231586, Free PMC Article
  3. The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Fellous A, et al. Gene, 2019 Mar 1. PMID 30458291
  4. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K4 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K4 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of histone methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone-lysine N-methyltransferase 2B; lysine (K)-specific methyltransferase 2Bb
Names
myeloid/lymphoid or mixed-lineage leukemia 4b
XP_002664717.2
XP_009290151.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    37457008..37543667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009291876.3 → XP_009290151.1  histone-lysine N-methyltransferase 2B isoform X2

    UniProtKB/TrEMBL
    A0A8M3AT01
    Conserved Domains (12) summary
    cd05493
    Location:1857 → 1979
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00317
    Location:3633 → 3753
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG2940
    Location:3605 → 3771
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    pfam02008
    Location:1407 → 1452
    zf-CXXC; CXXC zinc finger domain
    TIGR03835
    Location:455 → 958
    termin_org_DnaJ; terminal organelle assembly protein TopJ
    cd15589
    Location:1654 → 1700
    PHD1_KMT2B; PHD finger 1 found in Histone-lysine N-methyltransferase 2B (KMT2B)
    cd15591
    Location:1702 → 1750
    PHD2_KMT2B; PHD domain 2 found in Histone-lysine N-methyltransferase 2B (KMT2B)
    cd15593
    Location:1787 → 1843
    PHD3_KMT2B; PHD finger 3 found in Histone-lysine N-methyltransferase 2B (KMT2B)
    cd15664
    Location:2081 → 2185
    ePHD_KMT2A_like; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A) and 2B (KMT2B)
    pfam05964
    Location:2233 → 2279
    FYRN; F/Y-rich N-terminus
    pfam07223
    Location:2770 → 3107
    DUF1421; Protein of unknown function (DUF1421)
    cl02651
    Location:3469 → 3554
    FYRC; F/Y rich C-terminus

  2. XM_002664671.5 → XP_002664717.2  histone-lysine N-methyltransferase 2B isoform X1

    UniProtKB/TrEMBL
    A0A8M1RHP2, F8W580
    Related
    ENSDARP00000123759.1, ENSDART00000148870.3
    Conserved Domains (12) summary
    cd05493
    Location:1857 → 1979
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00317
    Location:3634 → 3754
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG2940
    Location:3606 → 3772
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    pfam02008
    Location:1407 → 1452
    zf-CXXC; CXXC zinc finger domain
    TIGR03835
    Location:455 → 958
    termin_org_DnaJ; terminal organelle assembly protein TopJ
    cd15589
    Location:1654 → 1700
    PHD1_KMT2B; PHD finger 1 found in Histone-lysine N-methyltransferase 2B (KMT2B)
    cd15591
    Location:1702 → 1750
    PHD2_KMT2B; PHD domain 2 found in Histone-lysine N-methyltransferase 2B (KMT2B)
    cd15593
    Location:1787 → 1843
    PHD3_KMT2B; PHD finger 3 found in Histone-lysine N-methyltransferase 2B (KMT2B)
    cd15664
    Location:2081 → 2185
    ePHD_KMT2A_like; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A) and 2B (KMT2B)
    pfam05964
    Location:2233 → 2279
    FYRN; F/Y-rich N-terminus
    pfam07223
    Location:2770 → 3107
    DUF1421; Protein of unknown function (DUF1421)
    cl02651
    Location:3470 → 3555
    FYRC; F/Y rich C-terminus
Nucleotide Protein
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