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gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 [ Danio rerio (zebrafish) ]

Gene ID: 566350, updated on 12-Sep-2024

Summary

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Official Symbol
gbf1provided by ZNC
Official Full Name
golgi brefeldin A resistant guanine nucleotide exchange factor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-081107-54
See related
Ensembl:ENSDARG00000027016 AllianceGenome:ZFIN:ZDB-GENE-081107-54
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:eu951; si:dkey-183c23.1
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within regulation of ARF protein signal transduction. Predicted to be located in Golgi apparatus. Is expressed in head. Orthologous to human GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (7575605..7749224)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (7243390..7413795)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene cyclic nucleotide-gated potassium channel Neighboring gene paired-like homeodomain 3 Neighboring gene macroH2A.2 histone Neighboring gene uncharacterized LOC137487364

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Highly conserved motifs within the large Sec7 ARF guanine nucleotide exchange factor GBF1 target it to the Golgi and are critical for GBF1 activity. Pocognoni CA, et al. Am J Physiol Cell Physiol, 2018 Jun 1. PMID 29443553, Free PMC Article
  2. Impairment of Cargo Transportation Caused by gbf1 Mutation Disrupts Vascular Integrity and Causes Hemorrhage in Zebrafish Embryos. Chen J, et al. J Biol Chem, 2017 Feb 10. PMID 28003365, Free PMC Article
  3. Comparative Study of the Molecular Characterization, Evolution, and Structure Modeling of Digestive Lipase Genes Reveals the Different Evolutionary Selection Between Mammals and Fishes. Tang SL, et al. Front Genet, 2022. PMID 35991544, Free PMC Article
  4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Residues within alpha-helix 2 and alpha-helix 6 of the HDS2 domain in GBF1 are novel regulatory determinants that support GBF1 cellular function by impacting the Golgi-specific membrane association of GBF1.
    Title: Highly conserved motifs within the large Sec7 ARF guanine nucleotide exchange factor GBF1 target it to the Golgi and are critical for GBF1 activity.
  2. endothelial endoplasmic reticulum stress and subsequent apoptosis induced by gbf1 deficiency may account for the vascular collapse and hemorrhage
    Title: Impairment of Cargo Transportation Caused by gbf1 Mutation Disrupts Vascular Integrity and Causes Hemorrhage in Zebrafish Embryos.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
Names
Golgi-specific brefeldin A-resistance factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    7575605..7749224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009307103.4 → XP_009305378.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A286Y9X1, A0A8M3AYU2
    Related
    ENSDARP00000143759.2, ENSDART00000175431.2
    Conserved Domains (3) summary
    COG5307
    Location:493 → 1170
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:709 → 894
    Sec7; Sec7 domain
    pfam12783
    Location:410 → 555
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  2. XM_009307106.4 → XP_009305381.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B513
    Conserved Domains (3) summary
    COG5307
    Location:493 → 1170
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:709 → 894
    Sec7; Sec7 domain
    pfam12783
    Location:410 → 555
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  3. XM_009307107.4 → XP_009305382.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AYV9
    Related
    ENSDARP00000120536.2, ENSDART00000146592.3
    Conserved Domains (3) summary
    COG5307
    Location:481 → 1158
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:697 → 882
    Sec7; Sec7 domain
    pfam12783
    Location:398 → 543
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  4. XM_009307108.4 → XP_009305383.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3BEH1
    Related
    ENSDARP00000046791.8, ENSDART00000046792.8
    Conserved Domains (3) summary
    COG5307
    Location:481 → 1158
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:697 → 882
    Sec7; Sec7 domain
    pfam12783
    Location:398 → 543
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
Nucleotide Protein Strain
Heading Accession and Version

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