c3b.2 complement component c3b, tandem duplicate 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: c3b.2provided by ZNC
Official Full Name: complement component c3b, tandem duplicate 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3063
See related: Ensembl:ENSDARG00000001818 AllianceGenome:ZFIN:ZDB-GENE-030131-3063
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc26b08; si:ch211-140f21.1
Summary: Predicted to enable endopeptidase inhibitor activity. Predicted to act upstream of or within complement activation. Predicted to be located in extracellular space. Is expressed in brain; gill; liver; pleuroperitoneal region; and post-vent region. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (26129245..26175320, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (26109348..26155393, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc26b08.x1 (e-PCR)
- UniSTS:193298

AI722358 (e-PCR)
- UniSTS:206012

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: complement component c3b, tandem duplicate 2

Names: c3.8; complement component 3-like; component c3b, duplicate 2; component c3b, tandem duplicate 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100020.1 → NP_001093490.1 complement component c3b, tandem duplicate 2 isoform 1 precursor

Status: PROVISIONAL

Source sequence(s)

BX649330

UniProtKB/TrEMBL

A0A8M1NF76, A5PMP8

Related

ENSDARP00000098698.4, ENSDART00000108737.6

Conserved Domains (8) summary

cd02896
Location:1004 → 1288

complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...

pfam00207
Location:768 → 861

A2M; Alpha-2-macroglobulin family

pfam01835
Location:150 → 243

A2M_N; MG2 domain

pfam07677
Location:1402 → 1495

A2M_recep; A-macroglobulin receptor

pfam07678
Location:1057 → 1288

A2M_comp; A-macroglobulin complement component

pfam07703
Location:490 → 621

A2M_N_2; Alpha-2-macroglobulin family N-terminal region

pfam12584
Location:886 → 916

TRAPPC10; Trafficking protein particle complex subunit 10, TRAPPC10

cl02512
Location:1515 → 1688

NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
NM_001114680.1 → NP_001108152.1 complement component c3b, tandem duplicate 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_001108152.1

Status: PROVISIONAL

Source sequence(s)

BC154024

UniProtKB/TrEMBL

A8KB97

Conserved Domains (1) summary

pfam01835
Location:150 → 243

A2M_N; MG2 domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

26129245..26175320 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009296391.3 → XP_009294666.1 complement component c3b, tandem duplicate 2 isoform X1

UniProtKB/TrEMBL

A0A8M3AN56

Conserved Domains (9) summary

cd00017
Location:692 → 748

ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...

cd02896
Location:1080 → 1364

complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...

pfam00207
Location:853 → 949

A2M; Alpha-2-macroglobulin family

pfam01835
Location:150 → 243

A2M_N; MG2 domain

pfam07677
Location:1481 → 1574

A2M_recep; A-macroglobulin receptor

pfam07678
Location:1133 → 1364

A2M_comp; A-macroglobulin complement component

pfam07703
Location:489 → 620

A2M_N_2; Alpha-2-macroglobulin family N-terminal region

pfam12584
Location:940 → 992

TRAPPC10; Trafficking protein particle complex subunit 10, TRAPPC10

cl02512
Location:1594 → 1767

NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
XM_005174032.3 → XP_005174089.1 complement component c3b, tandem duplicate 2 isoform X2

UniProtKB/TrEMBL

A0A8M2BLP7

Conserved Domains (9) summary

cd00017
Location:692 → 748

ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...

cd02896
Location:1080 → 1364

complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...

pfam00207
Location:853 → 949

A2M; Alpha-2-macroglobulin family

pfam01835
Location:150 → 243

A2M_N; MG2 domain

pfam07677
Location:1481 → 1574

A2M_recep; A-macroglobulin receptor

pfam07678
Location:1133 → 1364

A2M_comp; A-macroglobulin complement component

pfam07703
Location:489 → 620

A2M_N_2; Alpha-2-macroglobulin family N-terminal region

pfam12584
Location:940 → 992

TRAPPC10; Trafficking protein particle complex subunit 10, TRAPPC10

cl02512
Location:1594 → 1745

NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...