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stab2 stabilin 2 [ Danio rerio (zebrafish) ]

Gene ID: 565194, updated on 27-Mar-2024

Summary

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Official Symbol
stab2provided by ZNC
Official Full Name
stabilin 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-041210-336
See related
Ensembl:ENSDARG00000045748 AllianceGenome:ZFIN:ZDB-GENE-041210-336
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-207j16.6
Summary
Predicted to enable calcium ion binding activity and hyaluronic acid binding activity. Acts upstream of or within blood vessel endothelial cell differentiation and positive regulation of lymphangiogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including angioblastic mesenchymal cell; lateral plate mesoderm; post-vent region; vascular cord; and vasculature. Orthologous to human STAB2 (stabilin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See stab2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
68
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (10721542..10763547)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (10722946..10764698)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene cadherin-like and PC-esterase domain containing 1 Neighboring gene wingless-type MMTV integration site family, member 16 Neighboring gene uncharacterized LOC108183374 Neighboring gene stabilin-2-like Neighboring gene uncharacterized LOC110439354 Neighboring gene uncharacterized LOC108183376

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Stab2-Mediated Clearance of Supramolecular Polymer Nanoparticles in Zebrafish Embryos. Saez Talens V, et al. Biomacromolecules, 2020 Mar 9. PMID 32083854, Free PMC Article
  2. Stabilin-1 is required for the endothelial clearance of small anionic nanoparticles. Arias-Alpizar G, et al. Nanomedicine, 2021 Jun. PMID 33838334
  3. Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake. Campbell F, et al. ACS Nano, 2018 Mar 27. PMID 29320626, Free PMC Article
  4. HOXC9 regulates formation of parachordal lymphangioplasts and the thoracic duct in zebrafish via stabilin 2. Stoll SJ, et al. PLoS One, 2013. PMID 23484014, Free PMC Article
  5. Nuclear receptor subfamily 2 group F member 1a (nr2f1a) is required for vascular development in zebrafish. Wu BJ, et al. PLoS One, 2014. PMID 25157918, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HOXC9 regulates formation of parachordal lymphangioplasts and the thoracic duct in zebrafish via stabilin 2.
    Title: HOXC9 regulates formation of parachordal lymphangioplasts and the thoracic duct in zebrafish via stabilin 2.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables scavenger receptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables scavenger receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within blood vessel endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cholesterol homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within low-density lipoprotein particle clearance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within oxidised low-density lipoprotein particle clearance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within receptor-mediated endocytosis involved in cholesterol transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within receptor-mediated endocytosis involved in cholesterol transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
stabilin-2
Names
novel EGF-like domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290178.1 → NP_001277107.1  stabilin-2 precursor

    See identical proteins and their annotated locations for NP_001277107.1

    Status: PROVISIONAL

    Source sequence(s)
    FJ945321
    UniProtKB/TrEMBL
    C6GHV6
    Related
    ENSDARP00000067252.4, ENSDART00000067253.5
    Conserved Domains (4) summary
    smart00554
    Location:2310 → 2403
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:1742 → 1873
    Fasciclin; Fasciclin domain
    pfam12947
    Location:1465 → 1501
    EGF_3; EGF domain
    cl02612
    Location:2153 → 2245
    Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    10721542..10763547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021475053.1 → XP_021330728.1  stabilin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PUI5
    Conserved Domains (4) summary
    pfam02469
    Location:518 → 643
    Fasciclin; Fasciclin domain
    pfam12947
    Location:1465 → 1501
    EGF_3; EGF domain
    cl02663
    Location:1616 → 1694
    Fasciclin; Fasciclin domain
    cl21504
    Location:1358 → 1390
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  2. XM_017355051.2 → XP_017210540.1  stabilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YX27, F6P8Y7
    Related
    ENSDARP00000116540.2, ENSDART00000136000.4
    Conserved Domains (4) summary
    smart00554
    Location:2345 → 2438
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:1742 → 1873
    Fasciclin; Fasciclin domain
    pfam12947
    Location:2117 → 2154
    EGF_3; EGF domain
    cl02612
    Location:2188 → 2280
    Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394551.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    52915..98686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001110033.1: Suppressed sequence

    Description
    NM_001110033.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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