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serpina10a serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10a [ Danio rerio (zebrafish) ]

Gene ID: 565064, updated on 27-Mar-2024

Summary

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Official Symbol
serpina10aprovided by ZNC
Official Full Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041014-246
See related
Ensembl:ENSDARG00000005924 AllianceGenome:ZFIN:ZDB-GENE-041014-246
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-85n7.5
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in thrombophilia. Orthologous to human SERPINA10 (serpin family A member 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 20
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (27371783..27381642, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (27472693..27482552, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box containing 2a, tandem duplicate 1 Neighboring gene ankyrin repeat and SOCS box containing 2a, tandem duplicate 2 Neighboring gene protein phosphatase 4, regulatory subunit 4 Neighboring gene peripherin 2-like b Neighboring gene transmembrane protein 179a, genome duplicate A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease. Buglo E, et al. PLoS One, 2020. PMID 32208444, Free PMC Article
  2. Proteomic Profiling of Zebrafish Challenged by Spring Viremia of Carp Virus Provides Insight into Skin Antiviral Response. Liu R, et al. Zebrafish, 2020 Apr. PMID 32176570
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045071.2 → NP_001038536.2  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10a precursor

    See identical proteins and their annotated locations for NP_001038536.2

    Status: PROVISIONAL

    Source sequence(s)
    BC134976
    UniProtKB/TrEMBL
    A4IG87
    Related
    ENSDARP00000020541.8, ENSDART00000010293.11
    Conserved Domains (1) summary
    pfam00079
    Location:33 → 388
    Serpin; Serpin (serine protease inhibitor)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    27371783..27381642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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