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cbfa2t3 CBFA2/RUNX1 partner transcriptional co-repressor 3 [ Danio rerio (zebrafish) ]

Gene ID: 563252, updated on 17-Sep-2024

Summary

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Official Symbol
cbfa2t3provided by ZNC
Official Full Name
CBFA2/RUNX1 partner transcriptional co-repressor 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-070209-2
See related
Ensembl:ENSDARG00000079012 AllianceGenome:ZFIN:ZDB-GENE-070209-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable metal ion binding activity and transcription corepressor activity. Predicted to act upstream of or within negative regulation of transcription, DNA-templated and transcription, DNA-templated. Predicted to be located in nucleus. Orthologous to human CBFA2T3 (CBFA2/RUNX1 partner transcriptional co-repressor 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (55655430..55741658, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (55354019..55440312, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 2L Neighboring gene PABPN1 like, cytoplasmic Neighboring gene uncharacterized LOC137490678 Neighboring gene acyl-CoA synthetase family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Novel binding partners of Ldb1 are required for haematopoietic development. Meier N, et al. Development, 2006 Dec. PMID 17108004
  2. The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Wang Y, et al. Redox Biol, 2020 Jan. PMID 31539803, Free PMC Article
  3. Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Capon SJ, et al. Development, 2022 May 1. PMID 35531980, Free PMC Article
  4. Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Moore C, et al. Blood Adv, 2018 Oct 23. PMID 30309860, Free PMC Article
  5. Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Monteiro R, et al. Dev Cell, 2016 Aug 22. PMID 27499523, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein CBFA2T3
Names
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
eto2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    55655430..55741658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477980.2 → XP_021333655.2  protein CBFA2T3 isoform X3

  2. XM_021477979.2 → XP_021333654.2  protein CBFA2T3 isoform X2

    Related
    ENSDARP00000151083.1, ENSDART00000188631.1

  3. XM_021477978.2 → XP_021333653.2  protein CBFA2T3 isoform X1

  4. XM_021477981.2 → XP_021333656.1  protein CBFA2T3 isoform X4

    UniProtKB/TrEMBL
    A0A8M3BBB7, F1QTJ1
    Related
    ENSDARP00000009143.8, ENSDART00000021009.9
    Conserved Domains (4) summary
    pfam01753
    Location:517 → 553
    zf-MYND; MYND finger
    pfam07058
    Location:444 → 515
    MAP70; Microtubule-associated protein 70
    pfam07531
    Location:87 → 173
    TAFH; NHR1 homology to TAF
    pfam08788
    Location:312 → 378
    NHR2; NHR2 domain like

  5. XM_068222737.1 → XP_068078838.1  protein CBFA2T3 isoform X4

  6. XM_021477982.2 → XP_021333657.2  protein CBFA2T3 isoform X5

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394712.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    96011..185401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166575.5 → XP_005166632.2  protein CBFA2T3 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BE11
    Conserved Domains (4) summary
    pfam01753
    Location:560 → 596
    zf-MYND; MYND finger
    pfam07058
    Location:487 → 558
    MAP70; Microtubule-associated protein 70
    pfam07531
    Location:161 → 247
    TAFH; NHR1 homology to TAF
    pfam08788
    Location:386 → 452
    NHR2; NHR2 domain like

  2. XM_681892.9 → XP_686984.3  protein CBFA2T3 isoform X2

    UniProtKB/TrEMBL
    A0A8N7TCY0
    Conserved Domains (4) summary
    pfam01753
    Location:573 → 609
    zf-MYND; MYND finger
    pfam07531
    Location:161 → 247
    TAFH; NHR1 homology to TAF
    pfam08788
    Location:386 → 452
    NHR2; NHR2 domain like
    cl23750
    Location:501 → 565
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

  3. XM_009303491.4 → XP_009301766.2  protein CBFA2T3 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AUN0
    Conserved Domains (4) summary
    pfam01753
    Location:591 → 627
    zf-MYND; MYND finger
    pfam07058
    Location:518 → 589
    MAP70; Microtubule-associated protein 70
    pfam07531
    Location:161 → 247
    TAFH; NHR1 homology to TAF
    pfam08788
    Location:386 → 452
    NHR2; NHR2 domain like

  4. XM_009303492.4 → XP_009301767.1  protein CBFA2T3 isoform X4

    UniProtKB/TrEMBL
    A0A8M3BBB7, F1QTJ1
    Conserved Domains (4) summary
    pfam01753
    Location:517 → 553
    zf-MYND; MYND finger
    pfam07058
    Location:444 → 515
    MAP70; Microtubule-associated protein 70
    pfam07531
    Location:87 → 173
    TAFH; NHR1 homology to TAF
    pfam08788
    Location:312 → 378
    NHR2; NHR2 domain like

  5. XM_021472025.2 → XP_021327700.1  protein CBFA2T3 isoform X5

    UniProtKB/TrEMBL
    A0A8M9Q2N2
    Conserved Domains (2) summary
    pfam07531
    Location:161 → 247
    TAFH; NHR1 homology to TAF
    pfam08788
    Location:386 → 452
    NHR2; NHR2 domain like
Nucleotide Protein Strain
Heading Accession and Version

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