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cpda carboxypeptidase D, a [ Danio rerio (zebrafish) ]

Gene ID: 563008, updated on 25-Apr-2024

Summary

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Official Symbol
cpdaprovided by ZNC
Official Full Name
carboxypeptidase D, aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081112-2
See related
Ensembl:ENSDARG00000055648 AllianceGenome:ZFIN:ZDB-GENE-081112-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cpd
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Orthologous to human CPD (carboxypeptidase D). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (24756872..24794543)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (24821580..24859278)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 Neighboring gene golgi SNAP receptor complex member 1 Neighboring gene trafficking regulator of GLUT4 (SLC2A4) 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of the tbx6/16 subfamily genes in vertebrates: insights from zebrafish. Ahn D, et al. Mol Biol Evol, 2012 Dec. PMID 22915831
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carboxypeptidase D
XP_005157676.1
XP_021328621.1
XP_021328622.1
XP_021330023.1
XP_021330024.1
XP_691464.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    24756872..24794543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157619.4 → XP_005157676.1  carboxypeptidase D isoform X1

    UniProtKB/TrEMBL
    A0A8M9PSM1, E7F254
    Related
    ENSDARP00000072498.3, ENSDART00000078035.6
    Conserved Domains (4) summary
    cd03863
    Location:467 → 763
    M14_CPD_II; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain II subgroup
    cd03868
    Location:46 → 340
    M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup
    cd11308
    Location:344 → 420
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:895 → 1179
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

  2. XM_686372.9 → XP_691464.3  carboxypeptidase D isoform X2

    UniProtKB/TrEMBL
    A0A8M9PC21, X1WCL4
    Related
    ENSDARP00000127958.1, ENSDART00000156424.3
    Conserved Domains (4) summary
    cd03863
    Location:467 → 763
    M14_CPD_II; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain II subgroup
    cd03868
    Location:46 → 340
    M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup
    cd11308
    Location:344 → 420
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:895 → 1178
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394947.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    516110..553781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021472946.1 → XP_021328621.1  carboxypeptidase D isoform X1

    UniProtKB/TrEMBL
    A0A8M9PSM1, E7F254
    Conserved Domains (4) summary
    cd03863
    Location:467 → 763
    M14_CPD_II; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain II subgroup
    cd03868
    Location:46 → 340
    M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup
    cd11308
    Location:344 → 420
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:895 → 1179
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

  2. XM_021472947.1 → XP_021328622.1  carboxypeptidase D isoform X2

    UniProtKB/TrEMBL
    A0A8M9PC21, X1WCL4
    Conserved Domains (4) summary
    cd03863
    Location:467 → 763
    M14_CPD_II; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain II subgroup
    cd03868
    Location:46 → 340
    M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup
    cd11308
    Location:344 → 420
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:895 → 1178
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395323.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    107901..145572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474348.1 → XP_021330023.1  carboxypeptidase D isoform X1

    UniProtKB/TrEMBL
    A0A8M9PSM1, E7F254
    Conserved Domains (4) summary
    cd03863
    Location:467 → 763
    M14_CPD_II; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain II subgroup
    cd03868
    Location:46 → 340
    M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup
    cd11308
    Location:344 → 420
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:895 → 1179
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

  2. XM_021474349.1 → XP_021330024.1  carboxypeptidase D isoform X2

    UniProtKB/TrEMBL
    A0A8M9PC21, X1WCL4
    Conserved Domains (4) summary
    cd03863
    Location:467 → 763
    M14_CPD_II; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain II subgroup
    cd03868
    Location:46 → 340
    M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup
    cd11308
    Location:344 → 420
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:895 → 1178
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
Nucleotide Protein Strain
Heading Accession and Version

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