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pard3bb par-3 family cell polarity regulator beta b [ Danio rerio (zebrafish) ]

Gene ID: 562146, updated on 12-Sep-2024

Summary

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Official Symbol
pard3bbprovided by ZNC
Official Full Name
par-3 family cell polarity regulator beta bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-290
See related
AllianceGenome:ZFIN:ZDB-GENE-070912-290
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-285n22.1
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including establishment of cell polarity; establishment of centrosome localization; and establishment or maintenance of epithelial cell apical/basal polarity. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Orthologous to human PARD3B (par-3 family cell polarity regulator beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See pard3bb in Genome Data Viewer
Location:
chromosome: 9
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (14566338..15208117, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (14597376..15236919, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 6 (LAN blood group) b Neighboring gene neuropilin 2b Neighboring gene uncharacterized LOC137496459 Neighboring gene uncharacterized LOC137490343 Neighboring gene uncharacterized LOC137490344

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Foxc1a regulates zebrafish vascular integrity and brain vascular development through targeting amotl2a and ctnnb1. Duan X, et al. Microvasc Res, 2022 Sep. PMID 35724741
  2. Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish. Shi X, et al. Blood, 2015 May 7. PMID 25778530
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

General protein information

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Preferred Names
partitioning defective 3 homolog B
Names
partitioning-defective protein 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    14566338..15208117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478865.2 → XP_021334540.1  partitioning defective 3 homolog B isoform X3

    UniProtKB/TrEMBL
    A0A8M9QK08
    Conserved Domains (5) summary
    smart00228
    Location:188 → 276
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:387 → 467
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1 → 145
    DUF3534; Domain of unknown function (DUF3534)
    cl28087
    Location:881 → 1077
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    cl28575
    Location:410 → 539
    SdrC; Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]

  2. XM_009304543.4 → XP_009302818.1  partitioning defective 3 homolog B isoform X2

    UniProtKB/TrEMBL
    A0A8M3B2I8
    Conserved Domains (3) summary
    smart00228
    Location:188 → 276
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:387 → 467
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1 → 145
    DUF3534; Domain of unknown function (DUF3534)

  3. XM_685546.10 → XP_690638.6  partitioning defective 3 homolog B isoform X1

    UniProtKB/TrEMBL
    A0A8N7UUX7
    Conserved Domains (3) summary
    smart00228
    Location:188 → 276
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:387 → 467
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1 → 145
    DUF3534; Domain of unknown function (DUF3534)

  4. XM_021478866.2 → XP_021334541.1  partitioning defective 3 homolog B isoform X4

    UniProtKB/TrEMBL
    A0A8M9QFU7
    Conserved Domains (4) summary
    smart00228
    Location:130 → 218
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:329 → 409
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:15 → 87
    DUF3534; Domain of unknown function (DUF3534)
    cl28087
    Location:880 → 1076
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein
Heading Accession and Version

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