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arhgap36 Rho GTPase activating protein 36 [ Danio rerio (zebrafish) ]

Gene ID: 559813, updated on 17-Sep-2024

Summary

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Official Symbol
arhgap36provided by ZNC
Official Full Name
Rho GTPase activating protein 36provided by ZNC
Primary source
ZFIN:ZDB-GENE-060616-298
See related
Ensembl:ENSDARG00000059672 AllianceGenome:ZFIN:ZDB-GENE-060616-298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
arhgap6; zgc:136763
Summary
Predicted to act upstream of or within signal transduction. Orthologous to several human genes including ARHGAP36 (Rho GTPase activating protein 36). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 7
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (51364290..51461664, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (51089387..51186600, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene RAS-like, family 11, member A Neighboring gene ubiquitin specific peptidase 12b Neighboring gene NHS-like 2 Neighboring gene ribosomal protein S4 X-linked

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Arhgap36-dependent activation of Gli transcription factors. Rack PG, et al. Proc Natl Acad Sci U S A, 2014 Jul 29. PMID 25024229, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 36
Names
Rho GTPase activating protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044906.2 → NP_001038371.1  rho GTPase-activating protein 36 isoform 1

    See identical proteins and their annotated locations for NP_001038371.1

    Status: VALIDATED

    Source sequence(s)
    BC117647, CR381676
    UniProtKB/TrEMBL
    A0A8N7UY89, Q1ECW3
    Related
    ENSDARP00000077624.5, ENSDART00000083189.6
    Conserved Domains (1) summary
    cl02570
    Location:206 → 411
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  2. NM_001351681.2 → NP_001338610.1  rho GTPase-activating protein 36 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR318655, CR381676, CU075791
    UniProtKB/TrEMBL
    A0A8M1P9Q5
    Related
    ENSDARP00000146614.1, ENSDART00000193947.1
    Conserved Domains (1) summary
    cd04376
    Location:244 → 449
    RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    51364290..51461664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009303441.4 → XP_009301716.1  rho GTPase-activating protein 36 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AUJ1
    Conserved Domains (1) summary
    cd04376
    Location:244 → 449
    RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...

  2. XM_068222327.1 → XP_068078428.1  rho GTPase-activating protein 36 isoform X3

  3. XM_068222326.1 → XP_068078427.1  rho GTPase-activating protein 36 isoform X1

  4. XM_068222328.1 → XP_068078429.1  rho GTPase-activating protein 36 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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