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dcaf17 ddb1 and cul4 associated factor 17 [ Danio rerio (zebrafish) ]

Gene ID: 558828, updated on 17-Sep-2024

Summary

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Official Symbol
dcaf17provided by ZNC
Official Full Name
ddb1 and cul4 associated factor 17provided by ZNC
Primary source
ZFIN:ZDB-GENE-071008-1
See related
Ensembl:ENSDARG00000074909 AllianceGenome:ZFIN:ZDB-GENE-071008-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
c2orf37
Summary
Predicted to be involved in protein ubiquitination. Predicted to be located in nucleolus. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in Woodhouse-Sakati syndrome. Orthologous to human DCAF17 (DDB1 and CUL4 associated factor 17). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (3499080..3519767, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (3527555..3548188, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene integrin, alpha 6a Neighboring gene cytochrome b reductase 1 Neighboring gene methyltransferase 8, methylcytidine Neighboring gene tousled-like kinase 1a Neighboring gene glutamate decarboxylase 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DDB1- and CUL4-associated factor 17
Names
protein C2orf37 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144789.1 → NP_001138261.1  DDB1- and CUL4-associated factor 17

    See identical proteins and their annotated locations for NP_001138261.1

    Status: PROVISIONAL

    Source sequence(s)
    BX248116
    UniProtKB/Swiss-Prot
    A8WHR0
    Related
    ENSDARP00000121682.1, ENSDART00000145043.3
    Conserved Domains (1) summary
    pfam15802
    Location:44 → 518
    DCAF17; DDB1- and CUL4-associated factor 17

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    3499080..3519767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223398.1 → XP_068079499.1  DDB1- and CUL4-associated factor 17 isoform X2

  2. XM_068223397.1 → XP_068079498.1  DDB1- and CUL4-associated factor 17 isoform X2

  3. XM_068223396.1 → XP_068079497.1  DDB1- and CUL4-associated factor 17 isoform X1

  4. XM_068223395.1 → XP_068079496.1  DDB1- and CUL4-associated factor 17 isoform X1

  5. XM_017357683.3 → XP_017213172.1  DDB1- and CUL4-associated factor 17 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IWT1, A0A8M6Z0X3
    Related
    ENSDARP00000139615.2, ENSDART00000169586.2
    Conserved Domains (1) summary
    pfam15802
    Location:44 → 518
    DCAF17; DDB1- and CUL4-associated factor 17
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8WHR0.1 GenPept UniProtKB/Swiss-Prot:A8WHR0

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