U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

sptbn2 spectrin, beta, non-erythrocytic 2 [ Danio rerio (zebrafish) ]

Gene ID: 558044, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
sptbn2provided by ZNC
Official Full Name
spectrin, beta, non-erythrocytic 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-787
See related
Ensembl:ENSDARG00000053956 AllianceGenome:ZFIN:ZDB-GENE-030131-787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb48h06; wu:fb48h06; si:dkey-99p10.2
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of spectrin. Predicted to be active in several cellular components, including cell junction; cortical actin cytoskeleton; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 14 and spinocerebellar ataxia type 5. Orthologous to human SPTBN2 (spectrin beta, non-erythrocytic 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 5
Exon count:
44
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (37618814..37711847)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (37018635..37111694)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene latent transforming growth factor beta binding protein 3 Neighboring gene transfer RNA methionine (anticodon CAU) Neighboring gene transfer RNA methionine (anticodon CAU) Neighboring gene CDC42 effector protein (Rho GTPase binding) 2 Neighboring gene double PHD fingers 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways. Sánchez E, et al. Mol Neurobiol, 2018 Aug. PMID 29344929
  2. Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Farnsworth DR, et al. Exp Eye Res, 2021 May. PMID 33705730, Free PMC Article
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin filament capping IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament capping IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spectrin IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
spectrin beta chain, brain 1; spectrin family protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099989.1 → NP_001093459.1  spectrin family protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX276181, CT025939
    UniProtKB/TrEMBL
    A0A8M1NF56, F1QXB0
    Related
    ENSDARP00000088494.3, ENSDART00000097723.4
    Conserved Domains (6) summary
    smart00150
    Location:465 → 563
    SPEC; Spectrin repeats
    cd00014
    Location:213 → 316
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:997 → 1201
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:2230 → 2333
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:2230 → 2333
    PH; PH domain
    pfam00435
    Location:341 → 451
    Spectrin; Spectrin repeat

  2. NM_001423118.1 → NP_001410047.1  spectrin family protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX276181, CT025939, FP102018
    UniProtKB/TrEMBL
    A0A8M2BCP3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    37618814..37711847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165320.4 → XP_005165377.1  spectrin beta chain, brain 1 isoform X1

    Conserved Domains (6) summary
    smart00150
    Location:429 → 527
    SPEC; Spectrin repeats
    cd00014
    Location:177 → 280
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:961 → 1165
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:2228 → 2331
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:2228 → 2331
    PH; PH domain
    pfam00435
    Location:305 → 415
    Spectrin; Spectrin repeat

  2. XM_021476187.1 → XP_021331862.1  spectrin beta chain, brain 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PK72
    Related
    ENSDARP00000124243.1, ENSDART00000149151.3
    Conserved Domains (4) summary
    smart00150
    Location:429 → 527
    SPEC; Spectrin repeats
    COG5069
    Location:51 → 441
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:961 → 1165
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:2194 → 2297
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

  3. XM_021476188.1 → XP_021331863.1  spectrin beta chain, brain 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M9PXP3
    Conserved Domains (3) summary
    smart00150
    Location:2029 → 2087
    SPEC; Spectrin repeats
    COG5069
    Location:51 → 441
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:961 → 1165
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  4. XM_005165321.4 → XP_005165378.1  spectrin beta chain, brain 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BCL2
    Conserved Domains (6) summary
    smart00150
    Location:412 → 510
    SPEC; Spectrin repeats
    cd00014
    Location:160 → 263
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:944 → 1148
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:2211 → 2314
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:2211 → 2314
    PH; PH domain
    pfam00435
    Location:288 → 398
    Spectrin; Spectrin repeat
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.