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igf2bp2b insulin-like growth factor 2 mRNA binding protein 2b [ Danio rerio (zebrafish) ]

Gene ID: 557028, updated on 17-Sep-2024

Summary

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Official Symbol
igf2bp2bprovided by ZNC
Official Full Name
insulin-like growth factor 2 mRNA binding protein 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-536
See related
Ensembl:ENSDARG00000099758 AllianceGenome:ZFIN:ZDB-GENE-060503-536
Gene type
protein coding
RefSeq status
PREDICTED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb81e12; si:dkey-24b15.4
Summary
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in nervous system development; regulation of RNA metabolic process; and regulation of gene expression. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See igf2bp2b in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (30443195..30510921, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (29635497..29706982, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495518 Neighboring gene transmembrane protein 41ab Neighboring gene UBA domain containing 2 Neighboring gene G protein-coupled receptor 183b Neighboring gene dachshund c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The RNA Binding Protein Igf2bp1 Is Required for Zebrafish RGC Axon Outgrowth In Vivo. Gaynes JA, et al. PLoS One, 2015. PMID 26325373, Free PMC Article
  2. Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters. Sundström G, et al. BMC Evol Biol, 2008 Sep 19. PMID 18803835, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CRD-mediated mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC557028

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089374.1 → NP_001082843.1  uncharacterized protein LOC557028

    See identical proteins and their annotated locations for NP_001082843.1

    Status: PREDICTED

    Source sequence(s)
    BX088533
    UniProtKB/TrEMBL
    A0A0R4IVY2, A0A8M6Z590
    Related
    ENSDARP00000153857.1, ENSDART00000185318.1
    Conserved Domains (3) summary
    cd00105
    Location:31 → 94
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:267 → 327
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    TIGR03665
    Location:266 → 427
    arCOG04150; arCOG04150 universal archaeal KH domain protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    30443195..30510921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474969.2 → XP_021330644.1  uncharacterized protein LOC557028 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q0B6
    Conserved Domains (3) summary
    cd00105
    Location:31 → 94
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:266 → 326
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:348 → 411
    KH_1; KH domain

  2. XM_005159949.5 → XP_005160006.1  uncharacterized protein LOC557028 isoform X1

    See identical proteins and their annotated locations for XP_005160006.1

    UniProtKB/TrEMBL
    A0A0R4IVY2, A0A8M6Z590
    Related
    ENSDARP00000143916.1, ENSDART00000174868.2
    Conserved Domains (3) summary
    cd00105
    Location:31 → 94
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:267 → 327
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    TIGR03665
    Location:266 → 427
    arCOG04150; arCOG04150 universal archaeal KH domain protein

  3. XM_017354915.3 → XP_017210404.1  uncharacterized protein LOC557028 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IVY2, A0A8M6Z590
    Conserved Domains (3) summary
    cd00105
    Location:31 → 94
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:267 → 327
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    TIGR03665
    Location:266 → 427
    arCOG04150; arCOG04150 universal archaeal KH domain protein

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394491.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    324246..338301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395218.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    131724..145664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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