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stim1a stromal interaction molecule 1a [ Danio rerio (zebrafish) ]

Gene ID: 556360, updated on 25-Apr-2024

Summary

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Official Symbol
stim1aprovided by ZNC
Official Full Name
stromal interaction molecule 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-914
See related
Ensembl:ENSDARG00000060723 AllianceGenome:ZFIN:ZDB-GENE-060503-914
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-24p1.5
Summary
Predicted to enable calcium channel regulator activity and calcium ion binding activity. Acts upstream of with a positive effect on axon extension involved in axon guidance. Predicted to be located in membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including brain; head; liver; pleuroperitoneal region; and skeletal muscle. Human ortholog(s) of this gene implicated in Stormorken syndrome; immunodeficiency 10; and tubular aggregate myopathy 1. Orthologous to human STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 15
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (38221146..38297737)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (38319556..38394767)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic, alpha 10a Neighboring gene ras homolog family member Ga Neighboring gene si:dkey-24p1.6 Neighboring gene transient receptor potential cation channel subfamily C member 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. STIM1 Is Required for Remodeling of the Endoplasmic Reticulum and Microtubule Cytoskeleton in Steering Growth Cones. Pavez M, et al. J Neurosci, 2019 Jun 26. PMID 31023836, Free PMC Article
  2. SOCE proteins, STIM1 and Orai1, are localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos. Chan CM, et al. Zygote, 2016 Dec. PMID 27702423
  3. STIM1 activation of adenylyl cyclase 6 connects Ca(2+) and cAMP signaling during melanogenesis. Motiani RK, et al. EMBO J, 2018 Mar 1. PMID 29311116, Free PMC Article
  4. Identification of Zebrafish Calcium Toolkit Genes and their Expression in the Brain. Wasilewska I, et al. Genes (Basel), 2019 Mar 18. PMID 30889933, Free PMC Article
  5. Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae. Gupta RK, et al. Int J Mol Sci, 2020 Aug 27. PMID 32867296, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stim1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
    Title: SOCE proteins, STIM1 and Orai1, are localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_positive_effect axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
stromal interaction molecule 1; stromal interaction molecule 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044799.1 → NP_001038264.1  stromal interaction molecule 1a precursor

    Status: PROVISIONAL

    Source sequence(s)
    BX072550
    UniProtKB/TrEMBL
    A0A8M1N9C0, Q1LY88
    Related
    ENSDARP00000109796.2, ENSDART00000122134.4
    Conserved Domains (3) summary
    cd09573
    Location:122 → 195
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    pfam16533
    Location:338 → 435
    SOAR; STIM1 Orai1-activating region
    cl23720
    Location:227 → 330
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    38221146..38297737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173392.4 → XP_005173449.1  stromal interaction molecule 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BKP3
    Conserved Domains (3) summary
    cd09573
    Location:122 → 195
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    pfam16533
    Location:338 → 435
    SOAR; STIM1 Orai1-activating region
    cl23720
    Location:227 → 330
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. XM_009291871.3 → XP_009290146.1  stromal interaction molecule 1 isoform X3

    UniProtKB/TrEMBL
    A0A2R8RIM0, A0A8M3AHN3
    Related
    ENSDARP00000145787.1, ENSDART00000188149.1
    Conserved Domains (3) summary
    pfam16533
    Location:338 → 435
    SOAR; STIM1 Orai1-activating region
    cl15755
    Location:122 → 195
    SAM_superfamily; SAM (Sterile alpha motif )
    cl23720
    Location:227 → 330
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. XM_005173393.4 → XP_005173450.1  stromal interaction molecule 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BKR0
    Conserved Domains (3) summary
    cd09573
    Location:122 → 195
    SAM_STIM1; SAM domain of STIM1 subfamily proteins
    pfam16533
    Location:338 → 435
    SOAR; STIM1 Orai1-activating region
    cl23720
    Location:227 → 330
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Nucleotide Protein
Heading Accession and Version

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