tmie transmembrane inner ear [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tmieprovided by ZNC
Official Full Name: transmembrane inner earprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061207-9
See related: Ensembl:ENSDARG00000069423 AllianceGenome:ZFIN:ZDB-GENE-061207-9
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-163f10.1
Summary: Acts upstream of or within posterior lateral line neuromast primordium migration; sensory organ development; and sensory perception of sound. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in brain and otic vesicle. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 6 and sensorineural hearing loss. Orthologous to human TMIE (transmembrane inner ear). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (2223612..2279311)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (1881060..1936505)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

an early frameshift mutation in tmie discovered in a line of deaf and uncoordinated zebrafish with defective hair-cell function
Title: The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish.
Data show that transmembrane inner ear (tmie)appears to be required for inner ear development and function in the zebrafish and for hair cell maturation in the vestibular and lateral line systems as well.
Title: The transmembrane inner ear (tmie) gene contributes to vestibular and lateral line development and function in the zebrafish (Danio rerio).

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within auditory receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast primordium migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within semicircular canal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane inner ear expressed protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170647.1 → NP_001164118.1 transmembrane inner ear expressed protein isoform a

See identical proteins and their annotated locations for NP_001164118.1

Status: PROVISIONAL

Source sequence(s)

GQ389649

UniProtKB/TrEMBL

A2AVI6

Related

ENSDARP00000091812.4, ENSDART00000101038.6

Conserved Domains (1) summary

pfam16038
Location:64 → 139

TMIE; TMIE protein
NM_001170648.1 → NP_001164119.1 transmembrane inner ear expressed protein isoform b

See identical proteins and their annotated locations for NP_001164119.1

Status: PROVISIONAL

Source sequence(s)

GQ389648

UniProtKB/TrEMBL

D2ITC5

Related

ENSDARP00000112089.1, ENSDART00000129354.2

Conserved Domains (1) summary

pfam16038
Location:64 → 148

TMIE; TMIE protein

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

2223612..2279311

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480468.1 → XP_021336143.1 transmembrane inner ear expressed protein isoform X1

UniProtKB/TrEMBL

A0A8M9Q9E3

Conserved Domains (1) summary

pfam16038
Location:64 → 91

TMIE; TMIE protein