mmp23bb matrix metallopeptidase 23bb [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mmp23bbprovided by ZNC
Official Full Name: matrix metallopeptidase 23bbprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-448
See related: Ensembl:ENSDARG00000009825 AllianceGenome:ZFIN:ZDB-GENE-050417-448
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mmp23b; mmp23al; zgc:110623
Summary: Predicted to enable metalloendopeptidase activity. Acts upstream of or within liver development. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Is expressed in brain; liver; and notochord. Orthologous to human MMP23B (matrix metallopeptidase 23B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (45991028..46005525)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (45993010..46007507)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mmp23b is expressed in hepatocytes during development and its proper function is required for hepatocyte proliferation. mmp23b functions through the tumor necrosis factor (TNF) signaling pathway.
Title: Mmp23b promotes liver development and hepatocyte proliferation through the tumor necrosis factor pathway in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: matrix metallopeptidase 23bb

Names: matrix metallopeptidase 23a, like; matrix metallopeptidase 23b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017890.1 → NP_001017890.1 matrix metallopeptidase 23bb precursor

See identical proteins and their annotated locations for NP_001017890.1

Status: PROVISIONAL

Source sequence(s)

BC092954

UniProtKB/TrEMBL

Q567Z5

Related

ENSDARP00000017026.6, ENSDART00000024068.7

Conserved Domains (4) summary

cd04278
Location:67 → 234

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:67 → 234

Peptidase_M10; Matrixin

pfam01549
Location:234 → 269

ShK; ShK domain-like

cl11960
Location:287 → 358

Ig; Immunoglobulin domain