kcnab1a potassium voltage-gated channel subfamily A regulatory beta subunit 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kcnab1aprovided by ZNC
Official Full Name: potassium voltage-gated channel subfamily A regulatory beta subunit 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050327-79
See related: Ensembl:ENSDARG00000008140 AllianceGenome:ZFIN:ZDB-GENE-050327-79
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: kcnab1; zgc:113627
Summary: Predicted to enable aldo-keto reductase (NADP) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in negative regulation of delayed rectifier potassium channel activity. Predicted to act upstream of or within potassium ion transport; regulation of ion transmembrane transport; and transmembrane transport. Predicted to be located in cytoplasm and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in juxtaparanode region of axon. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in immature eye; myotome; nervous system; pharyngeal arch; and somite. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to human KCNAB1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (34290429..34536067)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (34386584..34559550)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aldo-keto reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in juxtaparanode region of axon	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: voltage-gated potassium channel subunit beta-1; voltage-gated potassium channel subunit beta-1a

Names: potassium voltage-gated channel, shaker-related subfamily, beta member 1 a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014354.1 → NP_001014376.1 voltage-gated potassium channel subunit beta-1a

See identical proteins and their annotated locations for NP_001014376.1

Status: PROVISIONAL

Source sequence(s)

BC091978

UniProtKB/TrEMBL

A0A8M1N4N5, Q58EC4

Related

ENSDARP00000122075.1, ENSDART00000131478.3

Conserved Domains (2) summary

cd06660
Location:70 → 385

Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...

TIGR01293
Location:70 → 386

Kv_beta; voltage-dependent potassium channel beta subunit, animal

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

34290429..34536067

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467646.1 → XP_021323321.1 voltage-gated potassium channel subunit beta-1 isoform X1

UniProtKB/TrEMBL

A0A8M9PM35

Conserved Domains (1) summary

TIGR01293
Location:90 → 390

Kv_beta; voltage-dependent potassium channel beta subunit, animal
XM_021467647.1 → XP_021323322.1 voltage-gated potassium channel subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A8M9P126

Conserved Domains (1) summary

TIGR01293
Location:90 → 406

Kv_beta; voltage-dependent potassium channel beta subunit, animal
XM_021467649.1 → XP_021323324.1 voltage-gated potassium channel subunit beta-1 isoform X4

UniProtKB/TrEMBL

A0A8M9PFF1

Conserved Domains (1) summary

TIGR01293
Location:78 → 394

Kv_beta; voltage-dependent potassium channel beta subunit, animal
XM_021467648.1 → XP_021323323.1 voltage-gated potassium channel subunit beta-1 isoform X3

UniProtKB/TrEMBL

A0A8M9PA23

Conserved Domains (1) summary

TIGR01293
Location:78 → 378

Kv_beta; voltage-dependent potassium channel beta subunit, animal
XM_021467650.1 → XP_021323325.1 voltage-gated potassium channel subunit beta-1 isoform X5

UniProtKB/TrEMBL

A0A8M9PQ73

Conserved Domains (1) summary

TIGR01293
Location:70 → 370

Kv_beta; voltage-dependent potassium channel beta subunit, animal