nbeaa neurobeachin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nbeaaprovided by ZNC
Official Full Name: neurobeachin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050320-68
See related: Ensembl:ENSDARG00000070080 AllianceGenome:ZFIN:ZDB-GENE-050320-68
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nbea; im:7138260; zgc:113510; si:ch211-125n11.1
Summary: Predicted to enable protein kinase binding activity. Acts upstream of or within dendrite development and synapse assembly. Predicted to be active in cytosol and membrane. Is expressed in nervous system; neural tube; and optic vesicle. Orthologous to human NBEA (neurobeachin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 60

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (34426256..34734995)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (34482383..34791135)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neurobeachin controls the asymmetric subcellular distribution of electrical synapse proteins.
Title: Neurobeachin controls the asymmetric subcellular distribution of electrical synapse proteins.
as a critical regulator in the postsynaptic neuron for the coordination of dendritic morphology with synaptogenesis
Title: Neurobeachin is required postsynaptically for electrical and chemical synapse formation.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neurobeachin a; neurobeachin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013500.2 → NP_001013518.2 neurobeachin a

Status: VALIDATED

Source sequence(s)

BX248233, BX293562, CT027816

UniProtKB/TrEMBL

A0A8M1N4S0, E7EZD1

Related

ENSDARP00000093342.4, ENSDART00000102566.5

Conserved Domains (8) summary

COG2319
Location:2687 → 2986

WD40; WD40 repeat [General function prediction only]

pfam02138
Location:2339 → 2615

Beach; Beige/BEACH domain

pfam06469
Location:2017 → 2184

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2210 → 2307

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:468 → 739

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:2776 → 2830

7WD40; WD40 repeat [structural motif]

cl02567
Location:2729 → 2986

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:251 → 398

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

34426256..34734995

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017357964.2 → XP_017213453.1 neurobeachin isoform X9

UniProtKB/TrEMBL

A0A8M6Z2X9
XM_009305434.3 → XP_009303709.1 neurobeachin isoform X2

UniProtKB/TrEMBL

A0A8M3B6C6

Conserved Domains (8) summary

COG2319
Location:2682 → 2981

WD40; WD40 repeat [General function prediction only]

pfam02138
Location:2339 → 2615

Beach; Beige/BEACH domain

pfam06469
Location:2017 → 2184

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2210 → 2307

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:468 → 739

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:2771 → 2825

7WD40; WD40 repeat [structural motif]

cl02567
Location:2724 → 2981

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:251 → 398

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
XM_009305432.3 → XP_009303707.1 neurobeachin isoform X1

UniProtKB/TrEMBL

A0A8M3AWW8

Conserved Domains (8) summary

COG2319
Location:2685 → 2984

WD40; WD40 repeat [General function prediction only]

pfam02138
Location:2337 → 2613

Beach; Beige/BEACH domain

pfam06469
Location:2015 → 2182

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2208 → 2305

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:468 → 739

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:2774 → 2828

7WD40; WD40 repeat [structural motif]

cl02567
Location:2727 → 2984

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:251 → 398

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
XM_009305437.3 → XP_009303712.1 neurobeachin isoform X5

UniProtKB/TrEMBL

A0A8M3BD56

Conserved Domains (8) summary

COG2319
Location:2647 → 2946

WD40; WD40 repeat [General function prediction only]

pfam02138
Location:2299 → 2575

Beach; Beige/BEACH domain

pfam06469
Location:1977 → 2144

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2170 → 2267

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:468 → 739

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:2736 → 2790

7WD40; WD40 repeat [structural motif]

cl02567
Location:2689 → 2946

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:251 → 398

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
XM_009305439.3 → XP_009303714.1 neurobeachin isoform X7

UniProtKB/TrEMBL

A0A8M3B6D2

Conserved Domains (8) summary

COG2319
Location:2642 → 2941

WD40; WD40 repeat [General function prediction only]

pfam02138
Location:2299 → 2575

Beach; Beige/BEACH domain

pfam06469
Location:1977 → 2144

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2170 → 2267

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:468 → 739

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:2731 → 2785

7WD40; WD40 repeat [structural motif]

cl02567
Location:2684 → 2941

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:251 → 398

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
XM_009305438.3 → XP_009303713.1 neurobeachin isoform X6

UniProtKB/TrEMBL

A0A8M3AWX2

Conserved Domains (8) summary

COG2319
Location:2645 → 2944

WD40; WD40 repeat [General function prediction only]

pfam02138
Location:2297 → 2573

Beach; Beige/BEACH domain

pfam06469
Location:1975 → 2142

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2168 → 2265

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:468 → 739

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:2734 → 2788

7WD40; WD40 repeat [structural motif]

cl02567
Location:2687 → 2944

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:251 → 398

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
XM_009305440.3 → XP_009303715.1 neurobeachin isoform X8

UniProtKB/TrEMBL

A0A8M3B3E6

Conserved Domains (8) summary

COG2319
Location:2640 → 2939

WD40; WD40 repeat [General function prediction only]

pfam02138
Location:2297 → 2573

Beach; Beige/BEACH domain

pfam06469
Location:1975 → 2142

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2168 → 2265

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:468 → 739

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:2729 → 2783

7WD40; WD40 repeat [structural motif]

cl02567
Location:2682 → 2939

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:251 → 398

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
XM_009305442.3 → XP_009303717.1 neurobeachin isoform X10

UniProtKB/TrEMBL

A0A8M3AWZ7

Conserved Domains (8) summary

COG2319
Location:2606 → 2905

WD40; WD40 repeat [General function prediction only]

pfam02138
Location:2263 → 2539

Beach; Beige/BEACH domain

pfam06469
Location:1941 → 2108

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2134 → 2231

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:468 → 739

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:2695 → 2749

7WD40; WD40 repeat [structural motif]

cl02567
Location:2648 → 2905

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:251 → 398

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
XM_009305435.3 → XP_009303710.1 neurobeachin isoform X3

UniProtKB/TrEMBL

A0A8M3B3E1

Conserved Domains (8) summary

COG2319
Location:2659 → 2958

WD40; WD40 repeat [General function prediction only]

pfam02138
Location:2311 → 2587

Beach; Beige/BEACH domain

pfam06469
Location:1989 → 2156

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2182 → 2279

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:468 → 739

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:2748 → 2802

7WD40; WD40 repeat [structural motif]

cl02567
Location:2701 → 2958

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:251 → 398

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
XM_009305436.3 → XP_009303711.1 neurobeachin isoform X4

UniProtKB/TrEMBL

A0A8M3AWZ2

Conserved Domains (8) summary

COG2319
Location:2651 → 2950

WD40; WD40 repeat [General function prediction only]

pfam02138
Location:2303 → 2579

Beach; Beige/BEACH domain

pfam06469
Location:1981 → 2148

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2174 → 2271

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:468 → 739

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:2740 → 2794

7WD40; WD40 repeat [structural motif]

cl02567
Location:2693 → 2950

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:251 → 398

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...