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Sulf1 Sulfated [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53437, updated on 10-May-2024

Summary

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Official Symbol
Sulf1provided by FlyBase
Official Full Name
Sulfatedprovided by FlyBase
Primary source
FLYBASE:FBgn0040271
Locus tag
Dmel_CG6725
See related
AllianceGenome:FB:FBgn0040271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6725; Dmel\CG6725; DSulf; Dsulf1; DSulf1; Neu5; sulf; Sulf-1; sulf1
Summary
Enables N-acetylglucosamine-6-sulfatase activity. Involved in several processes, including neuron development; regulation of signal transduction; and wing disc pattern formation. Located in extracellular space. Is expressed in several structures, including embryonic/larval nervous system; extended germ band embryo; presumptive embryonic/larval system; trunk ectoderm; and wing disc. Orthologous to human SULF1 (sulfatase 1) and SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Sulf1 in Genome Data Viewer
Location:
89B12-89B13; 3-58 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16310542..16339575, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12136264..12165297, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene gilgamesh Neighboring gene Zinc/iron regulated transporter-related protein 89B Neighboring gene transfer RNA:Phenylalanine-GAA 1-8 Neighboring gene transfer RNA:Valine-AAC 1-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Splicing factor 2 Neighboring gene uncharacterized protein Neighboring gene poils au dos Neighboring gene uncharacterized protein Neighboring gene Mesencephalic astrocyte-derived neurotrophic factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of Drosophila heparan sulfate 6-O-endosulfatase in sulfation compensation. Dejima K, et al. J Biol Chem, 2013 Mar 1. PMID 23339195, Free PMC Article
  2. Drosophila heparan sulfate 6-O-endosulfatase Sulf1 facilitates wingless (Wg) protein degradation. Kleinschmit A, et al. J Biol Chem, 2013 Feb 15. PMID 23300081, Free PMC Article
  3. The Drosophila Hox gene Ultrabithorax acts in both muscles and motoneurons to orchestrate formation of specific neuromuscular connections. Hessinger C, et al. Development, 2017 Jan 1. PMID 27913640, Free PMC Article
  4. Heparan sulfate regulates the number and centrosome positioning of Drosophila male germline stem cells. Levings DC, et al. Mol Biol Cell, 2016 Mar 15. PMID 26792837, Free PMC Article
  5. Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling. Kamimura K, et al. J Cell Biol, 2006 Sep 11. PMID 16966419, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sulf1 is required for terminating intestinal stem cell division at the end of regeneration.
    Title: Drosophila Sulf1 is required for the termination of intestinal stem cell division during regeneration.
  2. vertebrate and Drosophila Sulfs have an intrinsically similar activity and the function of Sulfs in the fate of Wnt/Wg ligands is context-dependent
    Title: Drosophila heparan sulfate 6-O-endosulfatase Sulf1 facilitates wingless (Wg) protein degradation.
  3. DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop.
    Title: DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop.
  4. The results demonstrate that sulf1 is a novel Wg target gene and by a feedback mechanism, it negatively regulated Wg signaling and distribution in vivo.
    Title: Sulfated is a negative feedback regulator of wingless in Drosophila.
  5. Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation
    Title: Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables N-acetylglucosamine-6-sulfatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in heparin metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic target inhibition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wing disc anterior/posterior pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wing disc dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sulfated
Names
CG6725-PA
CG6725-PB
CG6725-PC
HS 6-O-sulfatase 1
Sulf1-PA
Sulf1-PB
Sulf1-PC
NP_001262626.1
NP_001262627.1
NP_524987.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16310542..16339575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275698.1 → NP_001262627.1  sulfated, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262627.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MRG1, Q9NIH6, Q9VEX0
    UniProtKB/TrEMBL
    B7FNQ6, D1Z367
    Conserved Domains (4) summary
    COG3119
    Location:51 → 398
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:640 → 790
    DUF3740; Sulfatase protein
    cd16147
    Location:53 → 408
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:940 → 989
    ALP_like; alkaline phosphatases and sulfatases

  2. NM_080248.3 → NP_524987.1  sulfated, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524987.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MRG1, Q9NIH6, Q9VEX0
    UniProtKB/TrEMBL
    B7FNQ6, D1Z367
    Related
    FBpp0082725
    Conserved Domains (4) summary
    COG3119
    Location:51 → 398
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:640 → 790
    DUF3740; Sulfatase protein
    cd16147
    Location:53 → 408
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:940 → 989
    ALP_like; alkaline phosphatases and sulfatases

  3. NM_001275697.1 → NP_001262626.1  sulfated, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262626.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MRG1, Q9NIH6, Q9VEX0
    UniProtKB/TrEMBL
    B7FNQ6, D1Z367
    Conserved Domains (4) summary
    COG3119
    Location:51 → 398
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:640 → 790
    DUF3740; Sulfatase protein
    cd16147
    Location:53 → 408
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:940 → 989
    ALP_like; alkaline phosphatases and sulfatases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D1Z367 D1Z367
Q9VEX0.1 Q9VEX0

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