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D2HGDH D-2-hydroxyglutarate dehydrogenase [ Bos taurus (cattle) ]

Gene ID: 533003, updated on 5-Mar-2024

Summary

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Official Symbol
D2HGDHprovided by VGNC
Official Full Name
D-2-hydroxyglutarate dehydrogenaseprovided by VGNC
Primary source
VGNC:VGNC:27861
See related
BGD:BT24808; Ensembl:ENSBTAG00000002847
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
D2HGD
Orthologs
human mouse all
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Genomic context

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See D2HGDH in Genome Data Viewer
Location:
chromosome: 3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (120765589..120791784)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene deoxythymidylate kinase Neighboring gene inhibitor of growth family member 5 Neighboring gene galactose-3-O-sulfotransferase 2 Neighboring gene neuraminidase 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
D-2-hydroxyglutarate dehydrogenase, mitochondrial
NP_001069446.1
XP_005205097.1
XP_005205098.1
XP_010802205.1
XP_024845205.1
XP_059740649.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075978.1 → NP_001069446.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001069446.1

    Status: PROVISIONAL

    Source sequence(s)
    BT025420
    UniProtKB/Swiss-Prot
    Q1JPD3
    Conserved Domains (3) summary
    COG0277
    Location:92 → 542
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:124 → 261
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:298 → 538
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    120765589..120791784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005205041.5 → XP_005205098.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005205098.1

    UniProtKB/Swiss-Prot
    A5PKH4, Q1JPD3
    Conserved Domains (3) summary
    COG0277
    Location:92 → 542
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:124 → 261
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:298 → 538
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain

  2. XM_010803903.4 → XP_010802205.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_010802205.1

    UniProtKB/Swiss-Prot
    A5PKH4, Q1JPD3
    Conserved Domains (3) summary
    COG0277
    Location:92 → 542
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:124 → 261
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:298 → 538
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain

  3. XM_005205040.4 → XP_005205097.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005205097.1

    UniProtKB/Swiss-Prot
    A5PKH4, Q1JPD3
    Related
    ENSBTAP00000003690.4, ENSBTAT00000003690.6
    Conserved Domains (3) summary
    COG0277
    Location:92 → 542
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:124 → 261
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:298 → 538
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain

  4. XM_059884666.1 → XP_059740649.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X2

  5. XM_024989437.2 → XP_024845205.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X2

    Conserved Domains (1) summary
    COG0277
    Location:2 → 385
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1JPD3.2 GenPept UniProtKB/Swiss-Prot:Q1JPD3

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