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STRA6 signaling receptor and transporter of retinol STRA6 [ Bos taurus (domestic cattle) ]

Gene ID: 515911, updated on 17-Aug-2024

Summary

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Official Symbol
STRA6provided by VGNC
Official Full Name
signaling receptor and transporter of retinol STRA6provided by VGNC
Primary source
VGNC:VGNC:35417
See related
BGD:BT12061; Ensembl:ENSBTAG00000007348
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (34478073..34507705)

Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112443152 Neighboring gene coiled-coil domain containing 33 Neighboring gene coiled-coil domain-containing protein 33-like Neighboring gene immunoglobulin superfamily containing leucine rich repeat Neighboring gene uncharacterized LOC104969321 Neighboring gene immunoglobulin superfamily containing leucine rich repeat 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An essential ligand-binding domain in the membrane receptor for retinol-binding protein revealed by large-scale mutagenesis and a human polymorphism. Kawaguchi R, et al. J Biol Chem, 2008 May 30. PMID 18387951, Free PMC Article
  2. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Kawaguchi R, et al. Science, 2007 Feb 9. PMID 17255476
  3. Regulatory mechanism for the transmembrane receptor that mediates bidirectional vitamin A transport. Zhong M, et al. Proc Natl Acad Sci U S A, 2020 May 5. PMID 32300017, Free PMC Article
  4. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  5. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We found that the major protein repeatedly identified as STRA6-associated protein is calmodulin, consistent with the cryogenic electron microscopy (cryo-EM) study of zebrafish STRA6 associated with calmodulin
    Title: Regulatory mechanism for the transmembrane receptor that mediates bidirectional vitamin A transport.
  2. study identifies an essential functional domain in STRA6
    Title: An essential ligand-binding domain in the membrane receptor for retinol-binding protein revealed by large-scale mutagenesis and a human polymorphism.
  3. STRA6 was identified in retinal pigment epithelium cells as a specific membrane receptor for retinol binding protein (RBP); STRA6 binds to RBP with high affinity and has robust vitamin A uptake activity from the vitamin A-RBP complex
    Title: A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables retinol transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in vitamin A import into cell IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor for retinol uptake STRA6
Names
retinol-binding protein receptor STRA6
stimulated by retinoic acid 6
stimulated by retinoic acid gene 6 homolog
stimulated by retinoic acid gene 6 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075730.1 → NP_001069198.1  receptor for retinol uptake STRA6

    See identical proteins and their annotated locations for NP_001069198.1

    Status: PROVISIONAL

    Source sequence(s)
    BT026272
    UniProtKB/Swiss-Prot
    A5PK38, Q0V8E7
    UniProtKB/TrEMBL
    A0A3Q1M0A7
    Conserved Domains (1) summary
    pfam14752
    Location:42 → 656
    RBP_receptor; Retinol binding protein receptor

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    34478073..34507705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005221952.5 → XP_005222009.1  receptor for retinol uptake STRA6 isoform X1

    See identical proteins and their annotated locations for XP_005222009.1

    UniProtKB/TrEMBL
    A0A3Q1M0A7
    Conserved Domains (1) summary
    pfam14752
    Location:42 → 656
    RBP_receptor; Retinol binding protein receptor

  2. XM_010817072.4 → XP_010815374.1  receptor for retinol uptake STRA6 isoform X1

    See identical proteins and their annotated locations for XP_010815374.1

    UniProtKB/TrEMBL
    A0A3Q1M0A7
    Related
    ENSBTAP00000061392.2, ENSBTAT00000083847.2
    Conserved Domains (1) summary
    pfam14752
    Location:42 → 656
    RBP_receptor; Retinol binding protein receptor

  3. XM_010817071.3 → XP_010815373.1  receptor for retinol uptake STRA6 isoform X1

    See identical proteins and their annotated locations for XP_010815373.1

    UniProtKB/TrEMBL
    A0A3Q1M0A7
    Conserved Domains (1) summary
    pfam14752
    Location:42 → 656
    RBP_receptor; Retinol binding protein receptor

  4. XM_005221955.5 → XP_005222012.1  receptor for retinol uptake STRA6 isoform X1

    See identical proteins and their annotated locations for XP_005222012.1

    UniProtKB/TrEMBL
    A0A3Q1M0A7
    Related
    ENSBTAP00000089393.1, ENSBTAT00000130450.1
    Conserved Domains (1) summary
    pfam14752
    Location:42 → 656
    RBP_receptor; Retinol binding protein receptor

  5. XM_010817073.4 → XP_010815375.1  receptor for retinol uptake STRA6 isoform X1

    See identical proteins and their annotated locations for XP_010815375.1

    UniProtKB/TrEMBL
    A0A3Q1M0A7
    Conserved Domains (1) summary
    pfam14752
    Location:42 → 656
    RBP_receptor; Retinol binding protein receptor

  6. XM_024981766.2 → XP_024837534.1  receptor for retinol uptake STRA6 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M0A7
    Conserved Domains (1) summary
    pfam14752
    Location:42 → 656
    RBP_receptor; Retinol binding protein receptor

  7. XM_024981765.2 → XP_024837533.1  receptor for retinol uptake STRA6 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M0A7
    Conserved Domains (1) summary
    pfam14752
    Location:42 → 656
    RBP_receptor; Retinol binding protein receptor

  8. XM_010817069.3 → XP_010815371.1  receptor for retinol uptake STRA6 isoform X1

    See identical proteins and their annotated locations for XP_010815371.1

    UniProtKB/TrEMBL
    A0A3Q1M0A7
    Conserved Domains (1) summary
    pfam14752
    Location:42 → 656
    RBP_receptor; Retinol binding protein receptor

  9. XM_024981768.1 → XP_024837536.1  receptor for retinol uptake STRA6 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M0A7
    Conserved Domains (1) summary
    pfam14752
    Location:42 → 656
    RBP_receptor; Retinol binding protein receptor

  10. XM_005221954.4 → XP_005222011.1  receptor for retinol uptake STRA6 isoform X1

    See identical proteins and their annotated locations for XP_005222011.1

    UniProtKB/TrEMBL
    A0A3Q1M0A7
    Related
    ENSBTAP00000038534.3, ENSBTAT00000038724.4
    Conserved Domains (1) summary
    pfam14752
    Location:42 → 656
    RBP_receptor; Retinol binding protein receptor

  11. XM_024981767.2 → XP_024837535.1  receptor for retinol uptake STRA6 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1M0A7
    Conserved Domains (1) summary
    pfam14752
    Location:45 → 659
    RBP_receptor; Retinol binding protein receptor

  12. XM_024981770.1 → XP_024837538.1  receptor for retinol uptake STRA6 isoform X4

    UniProtKB/TrEMBL
    A0AAA9T165
    Conserved Domains (1) summary
    pfam14752
    Location:2 → 587
    RBP_receptor; Retinol binding protein receptor

  13. XM_010817074.4 → XP_010815376.1  receptor for retinol uptake STRA6 isoform X4

    See identical proteins and their annotated locations for XP_010815376.1

    UniProtKB/TrEMBL
    A0AAA9T165
    Conserved Domains (1) summary
    pfam14752
    Location:2 → 587
    RBP_receptor; Retinol binding protein receptor

  14. XM_059879055.1 → XP_059735038.1  receptor for retinol uptake STRA6 isoform X4

    UniProtKB/TrEMBL
    A0AAA9T165

  15. XM_024981769.2 → XP_024837537.1  receptor for retinol uptake STRA6 isoform X3

    UniProtKB/TrEMBL
    A0A3Q1M0A7, A0AAA9SJ91
    Related
    ENSBTAP00000085402.1, ENSBTAT00000106799.1
    Conserved Domains (1) summary
    pfam14752
    Location:5 → 619
    RBP_receptor; Retinol binding protein receptor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0V8E7.1 GenPept UniProtKB/Swiss-Prot:Q0V8E7

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