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ACE angiotensin I converting enzyme [ Bos taurus (domestic cattle) ]

Gene ID: 509484, updated on 17-Aug-2024

Summary

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Official Symbol
ACEprovided by VGNC
Official Full Name
angiotensin I converting enzymeprovided by VGNC
Primary source
VGNC:VGNC:107264
See related
BGD:BT14279; Ensembl:ENSBTAG00000024950
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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Genomic context

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Location:
chromosome: 19
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (47798612..47819230)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Neighboring gene uncharacterized LOC107131534 Neighboring gene uncharacterized LOC112442683 Neighboring gene uncharacterized LOC132343097 Neighboring gene cytochrome b561 Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 Neighboring gene potassium voltage-gated channel subfamily H member 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Testis-specific isoform of angiotensin-converting enzyme (tACE) is involved in the regulation of bovine sperm capacitation. Ojaghi M, et al. Mol Reprod Dev, 2017 May. PMID 28244620
  2. Characterization of the bovine angiotensin converting enzyme promoter: essential roles of Egr-1, ATF-2 and Ets-1 in the regulation by phorbol ester. Mungunsukh O, et al. Gene, 2008 Sep 15. PMID 18577431
  3. Evidence for the negative cooperativity of the two active sites within bovine somatic angiotensin-converting enzyme. Binevski PV, et al. FEBS Lett, 2003 Aug 28. PMID 12935891
  4. Bovine angiotensin-converting enzyme: amino-terminal sequence analysis and preliminary characterization of a hybridization-selected primary translation product. St Clair DK, et al. Biochem Biophys Res Commun, 1986 Dec 30. PMID 3028395
  5. Partial protein sequence of mouse and bovine kidney angiotensin converting enzyme. Bernstein KE, et al. Kidney Int, 1988 Mar. PMID 2835538

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a portion of the extracellular region of tACE (containing its catalytic site) is released from bovine sperm during capacitation, and tACE activity may be required for sperm capacitation.
    Title: Testis-specific isoform of angiotensin-converting enzyme (tACE) is involved in the regulation of bovine sperm capacitation.
  2. Phorbol 12-myristate 13-acetate (PMA) induced Egr-1 and ATF-2 binding to the ACE promoter, whereas Ets-1 binding was suppressed by PMA.
    Title: Characterization of the bovine angiotensin converting enzyme promoter: essential roles of Egr-1, ATF-2 and Ets-1 in the regulation by phorbol ester.
  3. The results indicate that the two active sites within bovine somatic ACE exhibit strong negative cooperativity.
    Title: Evidence for the negative cooperativity of the two active sites within bovine somatic angiotensin-converting enzyme.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptidyl-dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
angiotensin-converting enzyme
Names
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
dipeptidyl carboxypeptidase I
kininase II
NP_001193597.1
XP_024835648.1
XP_059733862.1
XP_059733863.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206668.1 → NP_001193597.1  angiotensin-converting enzyme precursor

    Status: PROVISIONAL

    Source sequence(s)
    CN792917, NKLS02000019
    UniProtKB/Swiss-Prot
    F1MQJ0, P12820, Q0GA41
    Conserved Domains (1) summary
    pfam01401
    Location:40 → 623
    Peptidase_M2; Angiotensin-converting enzyme

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    47798612..47819230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059877879.1 → XP_059733862.1  angiotensin-converting enzyme isoform X1

  2. XM_024979880.2 → XP_024835648.1  angiotensin-converting enzyme isoform X2

    UniProtKB/TrEMBL
    A0AAF6ZLS1
    Related
    ENSBTAP00000053314.4, ENSBTAT00000061106.4
    Conserved Domains (1) summary
    pfam01401
    Location:104 → 681
    Peptidase_M2; Angiotensin-converting enzyme

  3. XM_059877880.1 → XP_059733863.1  angiotensin-converting enzyme isoform X3

    UniProtKB/TrEMBL
    A0AAF6ZLS1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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