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Myo7b myosin VIIb [ Rattus norvegicus (Norway rat) ]

Gene ID: 498834, updated on 17-Aug-2024

Summary

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Official Symbol
Myo7bprovided by RGD
Official Full Name
myosin VIIbprovided by RGD
Primary source
RGD:1561153
See related
EnsemblRapid:ENSRNOG00000015035 AllianceGenome:RGD:1561153
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561153
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in several processes, including brush border assembly; sensory perception of sound; and vesicle transport along actin filament. Predicted to be located in apical cytoplasm and brush border. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and vesicle. Orthologous to human MYO7B (myosin VIIB). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 73.0), Liver (RPKM 21.4) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18p12
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (23862533..23944081, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (23588307..23669841, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (24742329..24823889, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 33 Neighboring gene SFT2 domain containing 3 Neighboring gene LIM zinc finger domain containing 2 Neighboring gene G protein-coupled receptor 17 Neighboring gene uncharacterized LOC134482980 Neighboring gene POTE ankyrin domain family, member F Neighboring gene interacts with SUPT6H, CTD assembly factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion. Crawley SW, et al. Cell, 2014 Apr 10. PMID 24725409, Free PMC Article
  2. A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Revenu C, et al. Mol Biol Cell, 2012 Jan. PMID 22114352, Free PMC Article
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brush border assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sound IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
unconventional myosin-VIIb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191941.1 → NP_001178870.1  unconventional myosin-VIIb

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I5ZSV6, F1M885
    Related
    ENSRNOP00000021405.6, ENSRNOT00000021405.9
    Conserved Domains (10) summary
    smart00015
    Location:787 → 809
    IQ; Calmodulin-binding motif
    smart00139
    Location:1646 → 1793
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00242
    Location:60 → 761
    MYSc; Myosin. Large ATPases
    smart00295
    Location:1802 → 2014
    B41; Band 4.1 homologues
    cd13198
    Location:1408 → 1504
    FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)
    cd13199
    Location:2010 → 2105
    FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)
    cd14473
    Location:1304 → 1405
    FERM_B-lobe; FERM domain B-lobe
    cd01381
    Location:79 → 750
    MYSc_Myo7; class VII myosin, motor domain
    pfam00373
    Location:1912 → 2014
    FERM_M; FERM central domain
    cl17036
    Location:1505 → 1565
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    23862533..23944081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254600.5 → XP_006254662.1  unconventional myosin-VIIb isoform X1

    UniProtKB/TrEMBL
    A0A0G2K3A7, A0A8I5ZSV6
    Related
    ENSRNOP00000072561.1, ENSRNOT00000090390.3
    Conserved Domains (10) summary
    smart00015
    Location:787 → 809
    IQ; Calmodulin-binding motif
    smart00139
    Location:1646 → 1793
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00242
    Location:60 → 761
    MYSc; Myosin. Large ATPases
    smart00295
    Location:1802 → 2014
    B41; Band 4.1 homologues
    cd13198
    Location:1408 → 1504
    FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)
    cd13199
    Location:2010 → 2105
    FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)
    cd14473
    Location:1304 → 1405
    FERM_B-lobe; FERM domain B-lobe
    cd01381
    Location:79 → 750
    MYSc_Myo7; class VII myosin, motor domain
    pfam00373
    Location:1912 → 2014
    FERM_M; FERM central domain
    cl17036
    Location:1505 → 1565
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

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